Prognostic Analysis of Different Metastatic Patterns in Invasive Intraductal Papillary Mucinous Neoplasm: A Surveillance, Epidemiology, and End Results Database Analysis
Table 2
Multivariate analyses of overall survival and pancreatic cancer-specific survival in patients with intraductal papillary mucinous neoplasm.
Features
OS
CSS
HR (95%CI)
value
HR (95%CI)
value
Metastasis
Isolated liver metastasis
1 (reference)
1 (reference)
Isolated lung metastasis
0.681 (0.564–0.822)
＜0.001
0.682 (0.545–0.852)
0.001
Isolated bone metastasis
0.469 (0.280–0.786)
0.004
0.551 (0.299–1.016)
0.056
Multiple
1.325 (1.098–1.600)
0.003
1.331 (1.080–1.640)
0.007
Other organ metastasis
0.784 (0.659–0.933)
0.006
0.785 (0.646–0.953)
0.015
Gender
Male
1 (reference)
1 (reference)
Female
1.014 (0.914–1.124)
0.796
1.007 (0.892–1.137)
0.909
Age (y)
＜60
1 (reference)
1 (reference)
≥60
1.347 (1.186–1.530)
＜0.001
1.271 (1.102–1.467)
0.001
Race
White
1 (reference)
1 (reference)
Black
0.950 (0.806–1.120)
0.542
0.884 (0.728–1.073)
0.213
Yellow
0.766 (0.639–0.920)
0.004
0.746 (0.605–0.919)
0.006
Marital
Married
1 (reference)
1 (reference)
Unmarried
1.107 (0.992–1.236)
0.069
1.129 (0.991–1.285)
0.067
Unknown
1.098 (0.867–1.391)
0.439
1.082 (0.828–1.414)
0.563
Primary Site
Head
1 (reference)
1 (reference)
Body/tail
1.079 (0.954–1.221)
0.228
1.155 (0.997–1.339)
0.055
Others
1.086 (0.955–1.234)
0.209
1.117 (0.960–1.299)
0.153
Surgery
No
1 (reference)
1 (reference)
Yes
0.201 (0.171–0.238)
<0.001
0.187 (0.153–0.230)
<0.001
Chemotherapy
No
1 (reference)
1 (reference)
Yes
0.594 (0.530–0.666)
<0.001
0.584 (0.511–0.668)
<0.001
Radiotherapy
No
1 (reference)
1 (reference)
Yes
1.079 (0.916–1.270)
364
1.168 (0.962–1.419)
0.116
Grade
I
1 (reference)
1 (reference)
II
1.220 (0.974–1.528)
0.084
1.189 (0.909–1.555)
0.207
III
1.357 (1.045–1.762)
0.022
1.315 (0.971–1.782)
0.077
IV
1.246 (0.606–2.559)
0.549
1.059 (0.385–2.909)
0.912
Unknown
0.939 (0.771–1.145)
0.536
0.892 (0.703–1.132)
0.347
For the Cox proportional model of OS, the value of test proportional hazards assumption was 0.1205 (). For the Cox proportional model of CSS, the value of test proportional hazards assumption was 0.0521 ().
