Clinical Characteristics and Prognosis of Concomitant Primary Biliary Cholangitis and Autoimmune Diseases: A Retrospective Study

Table 4

Univariate Cox proportional hazards regression analysis of prognostic factors for overall survival of patients with primary biliary cholangitis.

Characteristic/Parameters	RR	95% CI	value
Gender	0.656	0.429–1.002	0.051
Age	1.028	1.012–1.044	<0.001
Child–Pugh score	1.353	1.251–1.464	<0.001
ALT	0.999	0.998–1.000	0.156
AST	1.001	1.000–1.001	0.234
TBIL	1.004	1.003–1.005	<0.001
DBIL	1.005	1.004–1.007	<0.001
ALB	0.912	0.885–0.939	<0.001
GGT	1.000	0.999–1.000	0.648
ALP	1.000	0.999–1.001	0.480
WBC count	1.090	1.034–1.149	0.001
Hb	0.986	0.979–0.994	<0.001
PLT	0.994	0.992–0.997	<0.001
PT/INR	3.706	2.639–5.204	<0.001
CREA	1.011	1.007–1.014	<0.001
IgM	0.954	0.885–1.029	0.222
AMA	1.339	0.861–2.083	0.196
Fatigue	0.708	0.488–1.026	0.068
Pruritus	1.204	0.725–1.999	0.473
Cholangitis	1.328	0.745–2.368	0.336
Esophagogastric varices bleeding	1.960	1.118–3.435	0.019
Hepatic encephalopathy	2.569	1.680–3.927	0.001

ALT: serum alanine aminotransferase; AST: serum aspartate aminotransferase; TBIL: total bilirubin; DBIL: direct bilirubin; ALB: serum albumin; GGT: serum gamma-glutamyl transferase; ALP: serum alkaline phosphatase; WBC count: white blood cell count; Hb: serum hemoglobin; PLT: platelet count; PT/INR: prothrombin time and International normalized ratio; CREA: plasma creatinine; IgM: serum immunoglobulin M; AMA: antimitochondrial antibody-positive; SE: standard error; RR: relative risk or risk ratio; value < 0.05 was considered significant.