Systemic Inflammatory Response Syndrome in Patients Hospitalized for Acute Decompensation of Cirrhosis

Table 1

Characteristics of included patients and comparison according to the presence of SIRS.

	All (n = 543)	SIRS absent (n = 311)	SIRS present (n = 232)
Age (years), mean ± SD	55.4 ± 12.7	56.1 ± 12.3	54.4 ± 13.0	0.133
Male gender, (%)	64.5	64.0	65.1	0.791
Diabetes, (%)	40.9	44.1	37.4	0.196
Beta-blockers, (%)	44.7	50.2	37.3	0.003
Etiology of cirrhosis (%)
Hepatitis C	40.1	38.6	42.2	0.390
Hepatitis B Alc	5.4	6.1	4.3	0.362
Alcohol	47.1	43.4	52.2	0.043
Autoimmune hepatitis	3.7	4.2	3.0	0.477
Others	21.4	20.9	22.0	0.761
Complication at admission (%)
Ascites	60.2	58.8	62.1	0.257
Hepatic encephalopathy	45.0	39.7	52.2	0.004
Gastrointestinal bleeding	28.5	24.8	33.6	0.024
Bacterial infection (%)	47.3	36.0	62.5	<0.001
Laboratory data
Sodium (mEq/L), mean ± SD	134.6 ± 5.8	135.1 ± 5.4	134.0 ± 6.28	0.032
Albumin (g/dL), mean ± SD	2.4 ± 0.6	2.5 ± 0.6	2.3 ± 0.6	0.029
INR, median	1.5	1.4	1.5	0.029
Total bilirubin (mg/dL), median	2.1	1.9	2.5	0.038
Creatinine (mg/dL), median	1.1	1.0	1.2	0.004
Leukocyte count (x10^9), median	6.40	6.27	6.90	0.191
CRP (mg/L), median	7.3	6.3	39.1	<0.001
MELD score, mean ± SD	17.2 ± 7.0	16.3 ± 6.0	18.5 ± 7.9	<0.001
ACLF (%)	26.3	20.7	33.9	0.001
Child-Pugh classification
A	7.0	7.3	6.6	0.757
B	50.0	55.7	42.5	0.003
C	43.0	37.0	50.9	0.001
MAP (mmHg), mean ± SD	86.4 ± 15.4	86.8 ± 15.7	86.0 ± 15.0	0.552

SIRS = systemic inflammatory response syndrome; SD = standard deviation; INR = international normalised ratio; CRP = C-reactive protein; MELD = Model for End-Stage Liver Disease; ACFL = acute-on-chronic liver failure; MAP = mean arterial pressure.