Systemic Inflammatory Response Syndrome in Patients Hospitalized for Acute Decompensation of Cirrhosis

Table 2

Comparison of demographic, clinical, and laboratory data according to 90-day survival.

	Survivors (n = 377)	Nonsurvivors (n = 166)	HR (95% CI)
Age (years), mean ± SD	54.7 ± 12.8	57.0 ± 12.2	1.012 (0.999–1.025)	0.065
Male gender (%)	63.4	66.9	1.139 (0.825–1.574)	0.429
Diabetes (%)	39.9	43.2	1.124 (0.772–1.636)	0.543
Beta-blockers (%)	45.9	41.9	0.876 (0.640–1.199)	0.409
Complication at admission (%)
Ascites	50.9	81.3	3.450 (2.334–5.100)	<0.001
Hepatic encephalopathy	33.9	22.9	2.021 (1.483–2.775)	<0.001
Gastrointestinal bleeding	38.8	59.0	0.577 (0.394–0.844)	0.005
SIRS (%)	39.8	49.4	1.428 (1.053–1.936)	0.022
Bacterial infection (%)	20.7	40.4	2.995 (2.156–4.159)	<0.001
Laboratory data
Sodium (mEq/L), mean ± SD	135.6 ± 5.1	132.4 ± 6.6	0.927 (0.905–0.949)	<0.001
Albumin (g/dL), mean ± SD	2.5 ± 0.6	2.2 ± 0.6	0.455 (0.353–0.586)	<0.001
INR, median	1.4	1.7	1.880 (1.614–2.189)	<0.001
Total bilirubin (mg/dL), median	1.7	3.2	1.071 (1.054–1.089)	<0.001
Creatinine (mg/dL), median	1.0	1.5	1.343 (1.257–1.436)	<0.001
Leukocyte count (x10^9), median	6.11	7.47	1.055 (1.033–1.077)	<0.001
CRP (mg/L), median	6.0	10.5	1.006 (1.004–1.008)	<0.001
MELD score, mean ± SD	14.9 ± 5.2	22.4 ± 7.5	1.119 (1.100–1.138)	<0.001
ACLF (%)	14.7	52.4	4.321 (3.181–5.870)	<0.001
Child-Pugh C (%)	31.1	69.3	3.817 (2.734–5.330)	<0.001
MAP (mmHg), mean ± SD	87.2 ± 14.9	84.6 ± 16.3	0.996 (0.984–1.008)	0.518

HR = hazard ratio; SD = standard deviation; SIRS = systemic inflammatory response syndrome; INR = international normalised ratio; CRP = C-reactive protein; MELD = Model for End-Stage Liver Disease; ACFL = acute-on-chronic liver failure; MAP = mean arterial pressure.