Lactate and Bilirubin Index: A New Indicator to Predict Critically Ill Cirrhotic Patients’ Prognosis
Table 2
Laboratory parameters and clinical scores of the study population, stratified by survival.
Parameter
All patients (n = 479)
Survivors (n = 321)
Nonsurvivors (n = 158)
P value
Laboratory parameters
Hb (mg/dL)
9.9 (9.0–11.1)
10.0 (9.1–11.2)
9.8 (8.8–11.0)
0.104
WBC (109/L)
10.5 (7.4–15.7)
10.2 (7.3–14.4)
11.6 (7.7–19.1)
0.007
Platelet (109/L)
101.2 (70.3–152.0)
110.2 (74.3–162.0)
88.5 (62.3–129.0)
<0.001
INR
1.7 (1.5–2.1)
1.6 (1.4–1.9)
2.0 (1.7–2.7)
<0.001
PT (seconds)
18.0 (15.6–21.4)
16.8 (15.3–19.2)
20.6 (17.5–24.6)
<0.001
PTT (seconds)
39.5 (33.6–48.7)
37.4 (32.4–43.5)
45.3 (38.4–62.7)
<0.001
Glucose (mg/dL)
125.6 (103.0–157.8)
125.6 (103–156.5)
124.4 (101.2–158.0)
0.803
Sodium (mEq/L)
138.0 (134.0–141.0)
138.3 (135.6–141.2)
136.0(132.0–141.0)
<0.001
Potassium(mEq/L)
4.1 (3.7–4.5)
4.1 (3.7–4.4)
4.3 (3.8–4.8)
0.001
BUN (mg/dL)
29.5 (17.0–50.0)
25.3 (15.5–42.3)
41.7 (26.5–63.3)
<0.001
Creatinine (mg/dL)
1.3 (0.8–2.5)
1.1 (0.7–1.9)
1.9 (1.2–3.3)
<0.001
Albumin (g/dL)
2.8 (2.6–3.0)
2.8 (2.6–3.0)
2.8 (2.5–3.1)
0.702
Bilirubin (mg/dL)
3.3 (1.6–7.6)
2.7 (1.3–4.6)
7.3 (3.2–16.1)
<0.001
Lactate (mmol/L)
2.2 (1.6–3.7)
2.0 (1.5–3.0)
2.9 (2.0–6.0)
<0.001
Clinical scores
Child–Pugh
10 (9–11)
10 (9–11)
11 (10–11)
<0.001
SOFA
9 (6–11)
8 (6–10)
11 (9–14)
<0.001
CLIF-SOFA
9 (7–12)
9 (6–10)
12 (10–15)
<0.001
MELD
16 (10–25)
13 (8–20)
24 (16–33)
<0.001
LB index
5.9 (5.4–6.5)
5.7 (5.3–6.1)
6.6 (5.9–7.0)
<0.001
Values are expressed as n (%) or median (IQR). Hb: hemoglobin; WBC: white blood cell; INR: international normalized ratio; PT: prothrombin time; PTT: partial thromboplastin time; BUN: blood urea nitrogen; SOFA: sequential organ failure assessment; CLIF-SOFA: chronic liver failure-sequential organ failure assessment; MELD: model for end-stage liver disease; LB: lactate and bilirubin.
