Lactate and Bilirubin Index: A New Indicator to Predict Critically Ill Cirrhotic Patients’ Prognosis

Table 4

Diagnostic accuracy of different scoring systems in predicting 28-day mortality at the optimal cutoff point.

Prognostic models	AUROC (95% CI)	value	Cutoff point	Sensitivity	Specificity	PPV	NPV	PLR	NLR
LB index	0.791 (0.747–0.836)	—	6.18	0.70	0.79	0.61	0.84	3.24	0.39
Child–Pugh	0.624 (0.574–0.674)	<0.001	11	0.63	0.58	0.42	0.76	1.50	0.64
SOFA	0.771 (0.727–0.816)	0.372	10	0.70	0.72	0.55	0.83	2.48	0.42
CLIF-SOFA	0.775 (0.731–0.820)	0.455	10	0.80	0.66	0.53	0.87	2.33	0.31
MELD	0.768 (0.723–0.813)	0.271	18	0.72	0.69	0.53	0.83	2.32	0.40

DeLong test was used to compare the AUC between LB index and other clinical models. AUROC: area under the receiver operating characteristic curve; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; PLR: positive likelihood ratio; NLR: negative likelihood ratio; LB: lactate and bilirubin; SOFA: sequential organ failure assessment; CLIF-SOFA: chronic liver failure-sequential organ failure assessment; MELD: model for end-stage liver disease.