Liver Imaging and Data System (LI-RADS) Version 2018 and Other Imaging Features in Intrahepatic Cholangiocarcinoma in Chinese Adults with vs. without Chronic Hepatitis B Viral Infection
Table 3
Consensus MR imaging features of of iCCA in HBV-positive and HBV-negative patients.
Imaging features
HBV-positive group ()
HBV-negative group ()
value
LR-M features
Rim APHE
31 (62%)
27 (69%)
0.477
Peripheral “washout”
5 (10%)
2 (5%)
0.461
Delayed central enhancement
41 (82%)
37 (95%)
0.104
Targetoid appearance on DWI
31 (62%)
28 (72%)
0.332
Infiltrative appearance
11 (22%)
21 (54%)
0.002
Marked diffusion restriction
8 (16%)
3 (8%)
0.240
Necrosis or severe ischemia
30 (60%)
26 (67%)
0.518
At least one LR-M feature
44 (88%)
38 (97%)
0.103
LI-RADS major features of HCC
Nonrim APHE
12 (24%)
0 (0%)
0.001
Nonperipheral “washout”
8 (16%)
2 (5%)
0.109
Enhancing “capsule”
11 (22%)
3 (8%)
0.066
At least one major feature of HCC
23 (46%)
3 (8%)
<0.001
Ancillary features (AF) favoring malignancy in general
Restricted diffusion
50 (100%)
39 (100%)
NA
Mild-moderate T2 hyperintensity
50 (100%)
39 (100%)
NA
Corona enhancement
18 (36%)
30 (77%)
<0.001
Iron sparing in solid mass
0 (0%)
0 (0%)
NA
Fat sparing in solid mass
0 (0%)
0 (0%)
NA
At least one AF feature favoring malignancy in general
50 (100%)
39 (100%)
NA
LI-RADS ancillary features favoring HCC in particular
Intralesional fat
1 (2%)
0 (0%)
0.103
Blood products
3 (6%)
1 (3%)
0.628
Nodule-in-nodule
0 (0%)
0 (0%)
NA
Mosaic architecture
0 (0%)
0 (0%)
NA
Nonenhancing “capsule”
0 (0%)
0 (0%)
NA
At least one AF feature favoring HCC in particular
4 (8%)
1 (3%)
0.272
Others
Lobe
0.585
Right
27 (54%)
17 (44%)
Left
19 (38%)
19 (49%)
Both
4 (8%)
3 (8%)
Location
0.002
Subcapsular
34 (68%)
37 (95%)
Not subcapsular
16 (32%)
2 (5%)
Shape
0.001
Smooth
21 (42%)
4 (10%)
Lobulated/irregular
29 (58%)
35 (90%)
Liver surface retraction
11 (22%)
17 (44%)
0.03
Hepatic lobe atrophy
3 (6%)
7 (18%)
0.098
Satellite lesions
19 (38%)
10 (26%)
0.462
Lymph node metastasis
12 (24%)
13 (33%)
0.331
APHE, rim arterial phase hyperenhancement; DCE, delayed central enhancement; HBV, chronic hepatitis B virus infection. Data expressed as counts with percentages in parentheses.
