Molecular Pathogenesis of Intrahepatic Cholestasis of Pregnancy

Figure 1

The role of genetic regulatory factors in the pathogenesis of ICP. Estradiol (inhibited by LV-148a-siRNA) can upregulate miR-148a, and its potential targets are HLA-G and PXR; miR-590-3p can regulate the expression of VCAM-1; miR-21 and miR-29a can inhibit ICAM1. In addition, the CpG sites of FXR and PXR promoters are less methylated in ICP patients. For histone modification, the expression of HDAC3 in ICP is low. The question mark indicates that it has not been confirmed, the dotted line indicates the potential target, and the specific regulation path is shown in the arrow in the figure.