Ursodeoxycholic Acid at 18–22 mg/kg/d Showed a Promising Capacity for Treating Refractory Primary Biliary Cholangitis

Table 7

Percentage of biochemical relative changes from baseline at 12 months.

%Change from baseline	13–15 mg/kg/d	18–22 mg/kg/d	value
	(n = 36)	(n = 37)
TB, μ mol/L	8.30 (−18.41, 25.40)	2.25 (12.84, 25.52)	0.860
ALP, IU/L	19.89 (3.68, 39.27)	21.16 (6.49, 34.16)	0.830
GGT, IU/L	−27.90 (−2.25, 55.16)	31.86 (−18.08, 42.67)	0.643
AST, IU/L	20.42 (−12.83, 31.50)	23.81 (7.31, 33.33)	0.277
ALT, IU/L	20.71 (−18.46, 39.65)	28.57 (9.57, 39.29)	0.351
ALB, g/L	−1.88 (−4.96, 6.93)	−0.44 (−3.52, 7.15)	0.354
GLB, g/L	2.23 (−2.37, 11.19)	4.05 (−1.70, 10.62)	0.544
PLT, 10^9/L	11.67 (−0.49, 23.90)	1.72 (−18.03, 18.86)	0.075
IGM, mg/L	11.49 (−3.17, 20.14)	14.05 (8.18, 30.33)	0.120

Note. TB, total bilirubin; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALB, albumin; GLB, globulin; GGT, γ-glutamyltransferase; IGM, immunoglobulin M; PLT, platelet count.