Autoimmune Hepatitis with Elevated Serum IgG4 Levels Have a High Prevalence of Cirrhosis at Diagnosis
Table 2
Comparison of the age at onset, IgG4 level, cirrhosis prevalence, and other parameters between male and female patients.
Male (N = 28)
Female (N = 124)
value
Age at onset (years)
53.64 ± 15.998
50.7 ± 12.129
0.366
IgG4 g/L (NR ≤ 1.35)
1.37 (0.689–2.772)
0.676 (0.298–1.150)
0.002
IgG g/L (NR 8–15.5)
23.1 (18.075–26.8)
22.8 (17.375–30.975)
0.991
Cirrhosis n (%)
18 (64.29)
45 (36.29)
0.007
Time† (year)
1 (1–3)
1.5 (1–3.75)
0.688
Histology‡ (severity of inflammation)
N = 28
N = 118
—
G1 n (%)
3 (10.71)
11 (9.32)
1.000
G2 n (%)
6 (21.43)
31 (26.27)
0.596
G3 n (%)
18 (64.29)
69 (58.47)
0.573
G4 n (%)
1 (3.57)
6 (5.08)
1.000
Fibrosis stages at diagnosis
N = 28
N = 118
—
S0 n (%)
2 (7.14)
3 (2.54)
0.244
S1 n (%)
4 (14.28)
31 (26.27)
0.182
S2 n (%)
6 (21.43)
32 (27.12)
0.537
S3 n (%)
6 (21.43)
28 (23.73)
0.796
S4 n (%)
10 (35.71)
24 (20.34)
0.084
IgG, immunoglobulin G; IgG4, immunoglobulin G4. †The time interval between the onset time and the diagnosis time. ‡6 patients in the female group who did not receive liver biopsies were excluded.
