Autoimmune Hepatitis with Elevated Serum IgG4 Levels Have a High Prevalence of Cirrhosis at Diagnosis

Table 6

Comparison of baseline information between elderly and younger patients.

	Younger group (N = 117) (<65 years)	Elderly group (N = 35) (≥65 years)	value
Male n (%)	19 (16.24)	9 (25.71)	0.205
Cirrhosis n (%)	43 (36.75)	20 (57.14)	0.032
Asymptomatic presentation	39 (33.33)	11 (31.43)	0.833
PT (NR 9.6–12.8)	13. (11.9–150	13.4 (12.2–15.7)	0.359
ALT (IU/L) (NR < 40)	134 (57–303)	87 (38–164)	0.09
AST (IU/L) (NR < 35)	134 (61–292)	128 (69–299)	0.759
TB (umol/L) (NR 5–28)	30.6 (17.75–72.30)	30.9 (17.7–80.0)	0.738
ALP (IU/L) (NR 50- 135)	137 (94.5–175)	142 (103–174)	0.609
GGT (IU/L) (NR < 45)	96 (48–183)	136 (48–255)	0.243
ALB (g/L) (NR 40–55)	38.5 (32.25–42.85)	34.9 (29.9–41.7)	0.133
IgG (g/L) (NR 8–15.5)	22 (16.7–28)	24.8 (20.4–32.4)	0.017
IgG4 (g/L) (NR ≤ 1.35)	0.728 (0.348–1.16)	0.918 (0.338–2.84)	0.297
ANA positivity n (%)	85 (72.65)	28 (80.0)	0.382
Anti-LKM1 positivity n (%)	2 (1.71)	1 (2.86)	0.547
Anti-LC1 positivity n (%)	0 (0.00)	1 (2.86)	0.230
Anti-SLA/LP positivity n (%)	12 (12.82)	2 (5.71)	0.387
EAD n (%)	28 (23.93)	6 (17.1)	0.398
Remission^†n (%)	71 (73.20)	19 (79.17)	0.549

PT, prothrombin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TB, total bilirubin; ALP, alkaline phosphatase; GGT, gamma-glutamyl transferase; ALB, albumin; IgG4, immunoglobulin G4; ANA, anti-nuclear antibody; anti-LKM1, antibodies to liver kidney microsome type 1; anti-LC1, antibodies to liver cytosol type 1; anti-SLA/LP, antisoluble liver antigen/liver pancreas antibody; and EAD, extrahepatic autoimmune diseases. † There were 24 patients in the elderly group and 97 patients in the younger group who received regular treatment with a course of treatment longer than 6 months, respectively.