Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer

Table 1

Comparisons of the clinicopathologic features between adenocarcinoma with mixed subtypes and other histologic types, including classical adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma in early gastric cancer.

Variable	AM^a (%) N = 101	CA^b (%) N = 1110	MAC^c (%) N = 52	SRCC^d (%) N = 811	value	AM vs. CA, value	AM vs. MAC, value	AM vs. SRCC, value
Sex
Female	47 (46.5%)	458 (42.3%)	22 (41.3%)	423 (52.2%)	<0.001	0.303	0.619	0.286
Male	54 (53.5%)	652 (57.7%)	30 (58.7%)	388 (47.8%)
Age
<65	42 (41.6%)	263 (23.7%)	19 (36.5%)	433 (53.4%)	<0.001	<0.001	0.546	0.025
≥65	59 (58.4%)	847 (76.3%)	33 (63.5%)	378 (46.6%)
Race
White	53 (52.5%)	631 (56.8%)	40 (76.9%)	527 (65.0%)	0.001	0.675	0.013	0.033
Black	14 (13.9%)	148 (13.3%)	4 (8.0%)	99 (12.2%)
Others	34 (33.7%)	331 (29.8%)	8 (15.4%)	185 (22.8%)
Tumor size
<3 cm	59 (58.4%)	689 (62.1%)	20 (38.5%)	507 (62.5%)	0.018	0.765	0.057	0.507
3–6 cm	26 (25.7%)	257 (23.2%)	18 (34.6%)	168 (20.7%)
≥6 cm	16 (15.8%)	164 (14.8%)	14 (26.9%)	136 (16.8%)
Primary site
Antrum	27 (28.2%)	418 (26.3%)	14 (26.9%)	228 (25.9%)	<0.001	0.148	0.031	0.589
Pylorus	18 (13.3%)	146 (7.2%)	3 (5.8%)	116 (12.7%)
Body	20 (18.0%)	158 (37.8%)	24 (46.2%)	133 (17.9%)
Cardia	4 (3.1%)	46(2.9%)	2 (3.8%)	27 (2.8%)
Fundus	7 (6.0%)	60 (4.0%)	1 (1.9%)	58 (6.4%)
Lesser curve	8 (9.1%)	126 (6.7%)	2 (3.8%)	107 (12.8%)
Greater curve	16 (17.7%)	124 (13.3%)	6 (11.5%)	113 (17.6%)
Overlapping/not otherwise specified	1 (4.7%)	32 (1.9%)	0 (0%)	29 (4.1%)
N stage
N0	82 (81.1%)	992 (89.4%)	41 (78.8%)	689 (85.0%)	0.017	0.053	0.672	0.597
N1	13 (12.9%)	90 (8.1%)	6 (11.5%)	88 (10.9%)
N2	5 (5.0%)	20 (1.8%)	3 (5.8%)	23 (2.8%)
N3	1 (0.9%)	8 (0.7%)	2 (3.8%)	11 (13.6%)
M stage
M0	91 (85.6%)	1050 (94.6%)	43 (82.7%)	704 (86.8%)	<0.001	0.064	0.188	0.351
M1	10 (14.4%)	60 (5.4%)	9 (17.3%)	107 (13.2%)
Surgery
None	17 (16.8%)	134 (12.1%)	19 (36.5%)	221 (27.3%)	<0.001	0.038	0.043	0.008
Local tumor destruction	5 (5.0%)	110 (9.9%)	1 (1.9%)	10 (1.2%)
Partial gastrectomy	57 (56.4%)	708 (63.8%)	25 (48.1%)	419 51.7%)
Total gastrectomy	22 (21.8%)	158 (14.2%)	7 (13.5%)	161 (19.9%)

^aAdenocarcinoma with mixed subtypes; ^bclassical adenocarcinoma; ^cmucinous adenocarcinoma; ^dsignet-ring cell carcinoma.