Canadian Journal of Gastroenterology and Hepatology / 2021 / Article / Tab 2 / Research Article
Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer Table 2 Comparisons of the clinicopathologic features between adenocarcinoma with mixed subtypes and other histologic types, including classical adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma in advanced gastric cancer.
Variable AMa (%) N = 350 CAb (%) N = 1736 MACc (%) N = 324 SRCCd (%) N = 2195 valueAM vs. CA, value AM vs. MAC, value AM vs. SRCC, value Sex Female 132 (37.7%) 639 (36.8%) 95 (29.3%) 1025 (46.7%) <0.001 0.749 0.021 0.002 Male 218 (62.3%) 1097 (63.2%) 229 (70.7%) 1170 (53.3%) Age <65 155 (44.3%) 533 (30.7%) 134 (41.4%) 1270 (57.9%) <0.001 <0.001 0.443 <0.001 ≥65 195 (55.7%) 1203 (69.3%) 190 (58.6%) 925 (42.1%) Race White 221 (63.1%) 1027 (59.2%) 229 (70.7%) 1503 (68.5%) <0.001 0.355 0.080 0.015 Black 53 (15.1%) 278 (16.0%) 45 (13.9%) 252 (11.5%) Others 76 (21.7%) 431 (24.8%) 50 (15.4%) 440 (20.0%) Tumor size <3 cm 54 (15.4%) 321 (18.5%) 48 (14.8%) 508 (23.1%) <0.001 0.018 0.787 0.002 3–6 cm 89 (25.4%) 532 (30.6%) 90 (27.8%) 571 (26.0%) ≥6 cm 207 (59.1%) 883 (50.9%) 186 (57.4%) 1116 (50.8%) Primary site Antrum 100 (28.6%) 564 (32.5%) 85 (26.2%) 550 (25.1%) <0.001 0.038 <0.001 0.543 Pylorus 42 (12.0%) 208 (12.0%) 24 (7.4%) 266 (12.1%) Body 61 (17.4%) 230 (13.2%) 118 (36.4%) 404 (18.4%) Cardia 10 (2.9%) 87 (5.0%) 9 (2.8%) 56 (2.6%) Fundus 20 (5.7%) 83 (4.8%) 14 (4.3%) 131 (6.0%) Lesser curve 33 (9.4%) 228 (13.1%) 23 (7.1%) 279 (12.7%) Greater curve 64 (18.3%) 253 (14.6%) 44 (13.6%) 416 (19.0%) Overlapping/not otherwise specified 20 (5.7%) 83 (4.8%) 7 (2.2%) 93 (4.2%) T stage T2 52 (14.9%) 379 (21.8%) 58 (17.9%) 341 (15.5%) <0.001 <0.001 0.046 0.931 T3 149 (42.6%) 866 (49.9%) 158 (48.8%) 916 (41.7%) T4 149 (42.6%) 491 (28.3%) 108 (33.3%) 938 (42.7%) N stage N0 113 (32.3%) 806 (46.4%) 138 (42.6%) 854 (38.9%) <0.001 <0.001 0.002 0.063 N1 70 (2.0%) 379 (21.8%) 77 (23.8%) 447 (20.4%) N2 67 (19.1%) 274 (15.8%) 50 (15.4%) 341 (15.5%) N3 100 (28.6%) 277 (16.0%) 59 (18.2%) 553 (25.2%) M stage M0 295 (84.3%) 1510 (87.0%) 272 (84.0%) 1715 (78.1%) <0.001 0.178 0.905 0.009 M1 55 (15.7%) 226 (13.0%) 52 (16.0%) 480 (21.9%) Surgery None 43 (12.3%) 175 (10.1%) 44 (13.6%) 488 (22.2%) <0.001 0.280 0.458 <0.001 Local tumor destruction 2 (0.6%) 11 (0.6%) 4 (1.2%) 16 (0.7%) Partial gastrectomy 200 (57.1%) 1085 (62.5%) 194 (59.9%) 992 (45.2%) Total gastrectomy 105 (30.0%) 465 (26.8%) 82 (25.3%) 699 (31.8%)
a Adenocarcinoma with mixed subtypes; b classical adenocarcinoma; c mucinous adenocarcinoma; d signet-ring cell carcinoma.