Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer

Table 2

Comparisons of the clinicopathologic features between adenocarcinoma with mixed subtypes and other histologic types, including classical adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma in advanced gastric cancer.

Variable	AM^a (%) N = 350	CA^b (%) N = 1736	MAC^c (%) N = 324	SRCC^d (%) N = 2195	value	AM vs. CA, value	AM vs. MAC, value	AM vs. SRCC, value
Sex
Female	132 (37.7%)	639 (36.8%)	95 (29.3%)	1025 (46.7%)	<0.001	0.749	0.021	0.002
Male	218 (62.3%)	1097 (63.2%)	229 (70.7%)	1170 (53.3%)
Age
<65	155 (44.3%)	533 (30.7%)	134 (41.4%)	1270 (57.9%)	<0.001	<0.001	0.443	<0.001
≥65	195 (55.7%)	1203 (69.3%)	190 (58.6%)	925 (42.1%)
Race
White	221 (63.1%)	1027 (59.2%)	229 (70.7%)	1503 (68.5%)	<0.001	0.355	0.080	0.015
Black	53 (15.1%)	278 (16.0%)	45 (13.9%)	252 (11.5%)
Others	76 (21.7%)	431 (24.8%)	50 (15.4%)	440 (20.0%)
Tumor size
<3 cm	54 (15.4%)	321 (18.5%)	48 (14.8%)	508 (23.1%)	<0.001	0.018	0.787	0.002
3–6 cm	89 (25.4%)	532 (30.6%)	90 (27.8%)	571 (26.0%)
≥6 cm	207 (59.1%)	883 (50.9%)	186 (57.4%)	1116 (50.8%)
Primary site
Antrum	100 (28.6%)	564 (32.5%)	85 (26.2%)	550 (25.1%)	<0.001	0.038	<0.001	0.543
Pylorus	42 (12.0%)	208 (12.0%)	24 (7.4%)	266 (12.1%)
Body	61 (17.4%)	230 (13.2%)	118 (36.4%)	404 (18.4%)
Cardia	10 (2.9%)	87 (5.0%)	9 (2.8%)	56 (2.6%)
Fundus	20 (5.7%)	83 (4.8%)	14 (4.3%)	131 (6.0%)
Lesser curve	33 (9.4%)	228 (13.1%)	23 (7.1%)	279 (12.7%)
Greater curve	64 (18.3%)	253 (14.6%)	44 (13.6%)	416 (19.0%)
Overlapping/not otherwise specified	20 (5.7%)	83 (4.8%)	7 (2.2%)	93 (4.2%)
T stage
T2	52 (14.9%)	379 (21.8%)	58 (17.9%)	341 (15.5%)	<0.001	<0.001	0.046	0.931
T3	149 (42.6%)	866 (49.9%)	158 (48.8%)	916 (41.7%)
T4	149 (42.6%)	491 (28.3%)	108 (33.3%)	938 (42.7%)
N stage
N0	113 (32.3%)	806 (46.4%)	138 (42.6%)	854 (38.9%)	<0.001	<0.001	0.002	0.063
N1	70 (2.0%)	379 (21.8%)	77 (23.8%)	447 (20.4%)
N2	67 (19.1%)	274 (15.8%)	50 (15.4%)	341 (15.5%)
N3	100 (28.6%)	277 (16.0%)	59 (18.2%)	553 (25.2%)
M stage
M0	295 (84.3%)	1510 (87.0%)	272 (84.0%)	1715 (78.1%)	<0.001	0.178	0.905	0.009
M1	55 (15.7%)	226 (13.0%)	52 (16.0%)	480 (21.9%)
Surgery
None	43 (12.3%)	175 (10.1%)	44 (13.6%)	488 (22.2%)	<0.001	0.280	0.458	<0.001
Local tumor destruction	2 (0.6%)	11 (0.6%)	4 (1.2%)	16 (0.7%)
Partial gastrectomy	200 (57.1%)	1085 (62.5%)	194 (59.9%)	992 (45.2%)
Total gastrectomy	105 (30.0%)	465 (26.8%)	82 (25.3%)	699 (31.8%)

^aAdenocarcinoma with mixed subtypes; ^bclassical adenocarcinoma; ^cmucinous adenocarcinoma; ^dsignet-ring cell carcinoma.