Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer

Table 6

Results of competing risks regression with inclusion of possible risk factors in patients with advanced gastric cancer.

Variable	Subdistribution hazard ratio	value
Sex
Female	1 (reference)
Male	1.035 (0.950 − 1.129)	0.430
Age
<65	1 (reference)
≥65	1.307 (1.198 − 1.427)	<0.001
Race
White	1 (reference)
Black	1.010 (0.887 − 1.149)	0.880
Others	0.804 (0.722 − 0.895)	<0.001
Tumor size
<3 cm	1 (reference)
3–6 cm	1.189 (1.041 − 1.359)	0.011
≥6 cm	1.235 (1.090 − 1.399)	<0.001
Primary site
Antrum	1 (reference)
Pylorus	0.839 (0.720 − 0.977)	0.024
Body	0.930 (0.807 − 1.072)	0.320
Cardia	0.896 (0.713 − 1.126)	0.350
Fundus	0.841 (0.689 − 1.029)	0.093
Lesser curve	0.788 (0.677 − 0.916)	0.002
Greater curve	0.969 (0.858 − 1.095)	0.620
Overlapping/not otherwise specified	0.856 (0.696 − 1.053)	0.140
T stage
T2	1 (reference)
T3	1.687 (1.462 − 1.947)	<0.001
T4	2.350 (2.022 − 2.732)	<0.001
N stage
N0	1 (reference)
N1	1.156 (1.028 − 1.300)	0.016
N2	1.403 (1.231 − 1.599)	<0.001
N3	1.889 (1.679 − 2.126)	<0.001
M stage
M0	1 (reference)
M1	2.094 (1.878 − 2.334)	<0.001
Surgery
None	1 (reference)
Local tumor destruction	0.844 (0.537 − 1.327)	0.460
Partial gastrectomy	0.347 (0.304 − 0.397)	<0.001
Total gastrectomy	0.409 (0.357 − 0.469)	<0.001
Pathology
AM^a	1 (reference)
CA^b	0.769 (0.611 − 0.967)	<0.001
MAC^c	0.729 (0.611 − 0.869)	0.025
SRCC^d	1.045 (0.879 − 1.243)	0.620

^aAdenocarcinoma with mixed subtypes; ^bclassical adenocarcinoma; ^cmucinous adenocarcinoma; ^dsignet-ring cell carcinoma.