Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis

Table 1

Summary diagnostic accuracy parameter estimates and their 95% confidence intervals.

Subgroup		Sensitivity (95% CI)	Specificity (95% CI)	Positive LR (95% CI)	Negative LR (95% CI)	DOR (95% CI)	AUC
S1–S3
BMI ≥28	6	0.76 [0.69–0.81]	0.79 [0.70–0.86]	3.69 [2.41–5.66]	0.30 [0.23–0.41]	12.11 [6.08–24.12]	0.85 [0.81–0.88]
BMI <28	7	0.89 [0.83–0.93]	0.88 [0.80–0.93]	7.44 [4.24–13.06]	0.13 [0.07–0.21]	59.05 [22.16–159.76]	0.95 [0.92–0.96]
Cut-off ≥270	7	0.77 [0.73–0.81]	0.82 [0.78–0.86]	4.34 [3.45–5.46]	0.28 [0.23–0.33]	15.65 [11.33–21.60]	0.85 [0.83–0.89]
Cut-off <270	7	0.89 [0.85–0.92]	0.86 [0.74–0.89]	6.56 [3.20–13.47]	0.13 [0.10–0.17]	50.89 [21.26–121.84]	0.92 [0.89–0.94]
S2–S3
BMI ≥28	10	0.79 [0.73–0.84]	0.69 [0.62–0.75]	2.56 [2.09–3.13]	0.30 [0.23–0.38]	8.61 [6.07–2.21]	0.81 [0.77–0.84]
BMI <28	7	0.88 [0.78–0.94]	0.88 [0.78–0.90]	3.35 [2.60–4.31]	0.16 [0.09–0.31]	38.28 [25.84–56.70]	0.84 [0.80–0.87]
Cut-off ≥290	9	0.76 [0.70–0.82]	0.70 [0.64–0.75]	2.52 [2.15–2.95]	0.34 [0.27–0.42]	7.45 [5.56–9.97]	0.79 [0.75–0.82]
Cut-off <290	8	0.89 [0.75–0.81]	0.73 [0.63–0.81]	3.30 [2.33–4.65]	0.15 [0.09–0.25]	31.19 [5.23–17.08]	0.89 [0.86–0.92]
=S3
BMI ≥28	7	0.75 [0.69–0.80]	0.63 [0.52–0.73]	2.03 [1.60–2.58]	0.40 [0.33–0.47]	5.13 [3.62–7.26]	0.77 [0.73–0.80]
BMI <28	8	0.86 [0.74–0.93]	0.62 [0.54–0.69]	2.25 [1.90–2.67]	0.23 [0.13–0.42]	9.75 [5.05–18.81]	0.78 [0.74–0.81]
Cut-off ≥300	11	0.75 [0.70–0.79]	0.64 [0.56–0.71]	2.10 [1.74–2.54]	0.39 [0.33–0.46]	5.40 [3.98–7.32]	0.77 [0.73–0.80]
Cut-off <300	4	0.91 [0.85–0.95]	0.83 [0.77–0.87]	2.31 [1.84–2.89]	0.06 [0.01–0.73]	37.38 [3.29–424.09]	0.94 [0.92–0.96]

LR: likelihood ratio, DOR: diagnostic odds ratio, AUC: area under the curve, and CI: confidence interval.