Research Article

Anatomical Brain Changes and Cognitive Abilities in Patients with Obstructive Sleep Apnea Syndrome and Nonalcoholic Fatty Liver Disease

Table 1

Demographic parameters of examined population.

Group according to sleep apnea severityExaminedControlsTotalSignificance
(N = 68)(N = 76)(N = 144)

Parameter
Age (years ± SD)47.88 ± 6.0747.62 ± 6.9746.94 ± 9.00NS
Gender (male/female)58/1038/3896/48
Education level (grammar/high school/university)3/7/1225/33/1843/70/31NS
Body mass index (BMI, kg/m2)35.34 ± 7.3134.95 ± 8.2731.90 ± 6.61F = 807.33, DF = 3.140,
Leptin (ng/mL) m/f11.36 ± 1.97
22.78 ± 3.28
4.39 ± 2.17
11.44 ± 3.23
10.39 ± 2.53
14.55 ± 3.11
F = 5.66, DF = 3.140,
Adiponectin (ng/mL) m/f8.06 ± 0.97
11.14 ± 2.03
8.8 ± 1.44
13.71 ± 3.63
8.19 ± 2.44
11.43 ± 3.69
NS
Glucose (mmol/l)5.31 ± 0.655.75 ± 1.555.52 ± 1.28NS
C reactive protein (mg/l, mean ± SE)3.86 ± 1.273.74 ± 0.393.39 ± 0.25NS
Cholesterol (mmol/l, mean ± SD)5.19 ± 0.635.74 ± 1.185.57 ± 1.11NS
HDL (mmol/l, mean ± SE)0.95 ± 0.041.37 ± 0.071.18 ± 0.04F = 8.94, DF = 3.140,
LDL (mmol/l, mean ± SE)3.23 ± 0.173.27 ± 0.123.44 ± 0.08F = 2.76, DF = 3.140,
Triglycerides (mmol/l, mean ± SE)2.68 ± 0.351.86 ± 0.132.24 ± 0.12F = 7.64, DF = 3.140, p = 0.009
Cholesterol/HDL ratio (mean ± SE)6.02 ± 0.334.64 ± 0.185.27 ± 0.18F = 8.035, DF = 3.140,
Triglycerides/HDL ratio3.32 ± 0.481.62 ± 0.152.41 ± 0.19F = 7.71, DF = 3.140,
AIP0.520.210.38F = 8.01, DF = 3.140,
HDL/LDL ratio (mean ± SE)0.32 ± 0.030.43 ± 0.040.38 ± 0.02NS
AHI per hour (mean ± SE)12.23 ± 5.492.95 ± 0.1212.16 ± 1.31F = 29.44, DF = 3>140,
ODI per hour (mean ± SE)14.35 ± 4.512.78 ± 0.1311.08 ± 1.24F = 25.64, DF = 3.140,
Total brain volume (cm3, mean ± SE)1441.19 ± 32.311403.37 ± 18.851398.96 ± 13.16NS
MoCA score (mean ± SD)24.23 ± 3.1425.53 ± 3.2025.28 ± 3.04F = 2.72, DF = 3.140,

NS: not significant.