External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis
Table 1
Baseline clinical and demographic characteristics of both Slovak and Croatian and derivation cohorts.
Validation cohort (Slovak and Croatian patients, n = 194)
Derivation cohort (UK-PBC)
Female patients
165/194 (85.05%)
2409/2703 (89.1)
Age at diagnosis (years)
56.00 (49.00–62.00)
56.80 (49.52–64.16)
Total bilirubin (×ULN)
0.53 (0.43–0.76)
0.53 (0.37–0.76)
Aspartate transaminase (×ULN)
1.13 (0.85–1.67)
1.40 (0.90–2.25) (AT)
Alanine transaminase (×ULN)
1.23 (0.78–1.85)
1.40 (0.90–2.25) (AT)
Alkaline phosphatase (×ULN)
1.66 (1.18–2.54)
1.85 (1.21–3.25)
Gamma-glutamyl transferase (μkat/l)
4.38 (2.34-6.70)
—
Albumin (g/l)
43 (40.16–44.9)
41 (38–44)
Total cholesterol (mmol/l)
5.96 (5.24–6.80)
—
High-density lipoprotein cholesterol (mmol/l)
1.60 (1.31-1.84)
—
Low-density lipoprotein cholesterol (mmol/l)
3.63 (2.94–4.20)
—
Triglycerides (mmol/l)
1.24 (0.98–1.71)
Ferritin (pmol/l)
66.80 (26.78–118.80)
—
C-reactive protein (mg/l)
4.16 (2.93–8.70)
—
Immunoglobulin M (g/l)
3.54 (2.42–5.03)
—
Glycemia (mmol/l)
5.20 (4.83–5.97)
—
Platelets (×109/l)
241.00 (199.25–301.00)
—
Absolute neutrophil/lymphocyte count
1.89 (1.42–2.40)
—
Prothrombin time (INR)
0.99 (0.93–1.05)
—
Ursodeoxycholic acid dosage (mg/d)
1000 (750–1250)
—
Data are presented as median (interquartile ranges) or absolute counts (%). g/l: grams per liter, INR: international normalized ratio, mg/d: milligram per day, mg/l: milligram per liter, mmol/l: millimole per liter, μkat/l: microkatal per liter, n: number, pmol: picomole per liter, PT: prothrombin time, and ULN: upper limit of normal.
