Canadian Journal of Gastroenterology and Hepatology

Research Article

Comparison of General and Liver-Specific Prognostic Scores in Their Ability to Predict Mortality in Cirrhotic Patients Admitted to the Intensive Care Unit

Table 2

Comparison of survivors and nonsurvivors with cirrhosis admitted to the ICU.


Parameters	Survivors (n = 264)	Nonsurvivors (n = 118)	values

Age (years)	67.6 + 10.4.5	66.7 + 11.3	0.88
Male sex	200 (76%)	80 (68%)	0.11
Clinical features
Ascites	223 (85%)	98 (83%)	0.73
Bacterial infections/sepsis	130 (49%)	103 (87%)	<0.0001
Hepatic encephalopathy	128 (49%)	83 (70%)	<0.0001
Acute kidney injury	49 (19%)	70 (59%)	<0.0001
Variceal bleeding	13 (5%)	11 (9%)	0.11
AD of cirrhosis	181 (69%)	23 (20%)	<0.001
ACLF by CLIF criteria	83 (31%)	95 (80%)	< 0.001¹
(i) Grade I	59 (22%)	31 (26%)
(ii) Grade II	15 (6%)	21 (18%)
(iii) Grade III	9 (3%)	43 (36%)
ACLF by NACSELD criteria	3 (1%)	30 (25%)	<0.0001
Laboratory features
Serum sodium (mEq/L)	135.2 + 7.2	135.2 + 8,1	0.11
Serum creatinine (mg/dl)	1.2 + 1.0	1.8 + 1.4	<0.0001
Serum bilirubin (mg/dl)	3.1 + 4.0	5.7 + 7.0	<0.0001
Serum albumin(g/dl)	2.6 + 0.5	2.5 + 0.5	0.84
INR	1.8 + 0.9	2.2 + 1.5	0.01
Leukocyte count (109/L)	7512 + 4105	11808 + 7321	<0.0001
Organ support admission
Vasopressor therapy	4 (1, 5%)	13 (11%)	<0.0001
Mechanical ventilation	4 (2%)	24 (20%)	<0.0001
Scores
CCI	6.5 + 3.4	7.8 + 2.9	0.008
Apache II	13.1 + 3.9	18.3 + 8.6	0.001
CTP	9.6 + 2.2	11.1 + 1.7	0.02
MELD	17.8 + 6.2	24.6 + 8.6	0.001
MELD-Na	20.2 + 6.5	26.5 + 7.9	0.001
iMELD	41.9 + 9.4	47.0 + 12.4	<0.0001
MESO index	1.3 + 0.5	1.8 + 0.7	<0.0001
SOFA	3.7 + 2.0	6.1 + 3.0	<0.0001
CLIF-SOFA	4.1 + 2.1	6.9 + 3.1	<0.0001
CLIF-C OF	7.2 + 1.7	9.7 + 2.3	<0.0001
CLIC-C ACLF	44.6 + 10.0	50.4 + 13.1	0.03
CLIF-C AD	56.6 + 9.2	63.2 + 9.3	0.48

¹Chi-square for trend; AD, acute decompensation; ACLF, acute-on-chronic liver failure; CLIF-C, Chronic Liver Failure Consortium; NACSELD, North American Consortium for the Study of End-Stage Liver Disease; CCI, Charlson comorbidities index; APACHE II, Acute Physiology and Chronic Health Evaluation II; MELD, Model for End-Stage Liver Disease; MELD-Na, sodium MELD; MESO index, MELD to serum sodium ratio index; iMELD, integrated-MELD; CTP, Child–Turcotte–Pugh; SOFA, Sequential Organ Failure Assessment; CLIF-SOFA, CLIF Sequential Organ Failure Assessment; CLIF-C OF, CLIF-C organ failure; CLIF-C ACLF, CLIF acute-on-chronic liver failure; CLIF-C AD, CLIF-C acute decompensation; ICU, intensive care unit.