Comparison of General and Liver-Specific Prognostic Scores in Their Ability to Predict Mortality in Cirrhotic Patients Admitted to the Intensive Care Unit
Table 5
Cut-off points, sensibility, specificity, area under curve, and positive predictive value (to predict mortality) of the quintiles of APACHE II, MELD-Na, SOFA, CLIF-SOFA, CLIF-C ACLF, and CLIF-C AD scores.
Score
20th
40th
60th
80th
Co
Se
Sp
AUC
PPV
Co
Se
Sp
AUC
PPV
Co
Se
Sp
AUC
PPV
Co
Se
Sp
AUC
PPV
All patients (N = 382)
APACHE II
10
86.4
25.3
0.558
36.1
12
70.0
47.1
0.586
39.3
15
56.4
72.9
0.646
50.4
18
38.2
91.1
.646
67.7
MELD-Na
15.4
93.2
25.7
0.594
36.2
19.5
76.3
47.5
0.619
39.6
23.4
63.6
70.5
0.670
49.3
29.0
40.7
89.7
0.652
64.0
SOFA
2
94.1
26,9
0.605
36.5
4
70.3
67.4
0.689
49.1
5
51,7
83,8
0.675
58.1
6
37.3
93.2
0.652
71.0
CLIF-SOFA
3
87.3
39.0
0.632
39.0
4
77.1
60.2
0.687
46.4
5
65.3
76.1
0.707
55.0
7
36.4
95.5
0.659
78.2
CLIF-C OF
6
94.1
29.9
0.620
37.5
7
80.5
60.2
0.704
47.5
8
66.9
79.9
0.734
59.8
10
30.5
98.1
0.643
87.8
Patients with ACFL (N = 178)
APACHE II
12
76.4
39.7
0.581
60.7
14
67.4
52.1
0.597
63.2
17
47.2
82.2
0.647
76.4
21.4
30.3
93.2
0.617
84.4
MELD-Na
18.1
85.3
25.3
0.553
56.6
23.7
66.3
47.0
0.567
58.9
28.4
47.4
68.7
0.580
63.4
32.3
29.5
91.6
0.605
80.0
SOFA
3
84.2
32.5
0.584
58.5
5
53.7
68.7
0.612
66.2
6
40.0
83.1
0.616
73.1
7
24.2
95.2
0.597
85.2
CLIF-SOFA
4
81.1
37.3
0.592
59.7
6
56.8
74.7
0.658
72.0
7
41.1
88.0
0.645
79.6
8
27.4
96.4
0.619
89.7
CLIF-C OF
8
74.7
55.4
0.651
65.7
9
61.1
84.3
0.727
81.7
9.4
61.1
84.3
0.727
81.7
11
23.2
97.6
0.604
91.7
CLIF-CACLF
39.2
83.2
23.2
0.532
55.6
46.2
68.4
51.2
0.598
61.9
52.0
51.6
73.2
0.624
69.0
56.9
31.6
93.9
0.627
85.7
Patients with AD of cirrhosis (N = 204)
APACHE II
10
61.9
28.3
0.451
10.7
11.2
57.1
39.5
0.483
11.5
13
42.9
63.8
0.533
14.1
16
33.3
87.5
0.604
26.9
MELD-Na
14.1
95.7
21.9
0.588
13.7
17.9
78.3
42.1
0.602
14.9
20.3
56.5
62.4
0.594
16.3
23.6
43.5
83.1
0.633
25.0
SOFA
2
87.0
30.9
0.589
13.8
3
69.6
54.1
0.619
16.2
4
56.5
75.7
0.661
22.8
5
43.5
90.1
0.668
35.7
CLIF-SOFA
2
95.7
26.0
0.608
14.1
3
69.6
45.3
0.574
13.9
4
60.9
70.7
0.658
20.9
5
47.8
88.4
0.681
34.4
CLIF-C OF
6
87.0
37.0
0.620
14.9
7
47.8
75.1
0.615
19.6
7
47.8
75.1
0.615
19.6
8
34.8
91.2
0.630
33.3
CLIF-CAD
50
87.0
21.5
0.542
12.6
54.4
73.9
41.8
0.579
14.2
58
65.2
63.8
0.645
19.0
64.9
52.2
84.2
0.682
30.0
Co = cut-off; Se=sensibility; Sp = specificity; AUC = area under curve; PPV = positive predictive value.
