LncRNA SNHG17 Contributes to Proliferation, Migration, and Poor Prognosis of Hepatocellular Carcinoma

Figure 5

RNA sequencing and bioinformatics analysis explore the downstream genes regulated by SNHG17 in HCC. (a) Mean-centered, hierarchical clustering of 1037 genes altered (≥2-fold change, ) after knockdown of SNHG17 in Hep3B cells, with three repeats. (b) The (A) Venn diagrams represent the overlap of downregulated genes in RNA-seq data and SNHG17-positive-related genes in TCGA-LIHC. The (B) Venn diagrams represent the overlap of upregulated genes in RNA-seq data and SNHG17-negative-related genes in TCGA-LIHC. (c) qRT-PCR was performed to detect the expression of indicated genes in (A) PLC/PRF/5 and (B) Hep3B cells. (d) qRT-PCR was performed to detect the expression of indicated genes in (A) SMMC-7721 and (B) HuH-7 cells. , , , and NS, not significant.

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