Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B

Table 4

Univariate and multivariate analyses producing odds ratio for significant F4 stage in chronic HBV patients.

Variables	Univariate analysis RR (95% C.I.)	value	Multivariate analysis RR (95% C.I)	value
AFP	1.02 (1.01–1.04)	0.001
Alb	0.84 (0.77–0.92)	0.000	0.85 (0.74–0.97)	0.019
ALP	1.01 (1.00–1.01)	0.034
ALT	1.00 (1.00–1.00)	0.016
AST	1.00 (1.00–1.00)	0.010
CHE	1.00 (1.00–1.00)	0.001
CIV	1.01 (1.00–1.01)	0.001
G	14.83 (4.51–48.76)	0.000	5.55 (1.56–19.67)	0.008
Hb	0.96 (0.93–0.99)	0.016
Neutrophil	0.60 (0.40–0.88)	0.010
PLT	0.98 (0.98–0.99)	0.001
PTA	0.98 (0.96–0.99)	0.009
RBC	0.16 (0.06–0.41)	0.000
sGDNF	13.33 (4.76–37.34)	0.000	6.98 (1.10–17.94)	0.036
TBA	1.01 (1.00–1.02)	0.009
TBil	1.04 (1.02–1.07)	0.001
WBC	0.60 (0.43–0.86)	0.005

All baseline covariates were included in the univariable analysis (two-sided value < 0.05). Only covariates significantly associated with F4 in the univariable analysis (two-sided value < 0.05) are shown and included in the multivariable model. Alb, albumin, AFP, alpha fetoprotein; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CHE, cholinesterase; CIV, type IV collagen; Hb, hemoglobin; PLT, platelet count; PTA, prothrombin activity; RBC, red blood cell count; TBA, total bile acid; TBil, total bilirubin; WBC, white blood cell count.