Canadian Journal of Gastroenterology and Hepatology

Research Article

Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B

Table 5

Areas under the receiver operating characteristic curve for the diagnostic accuracy of sGDNF, APRI, FIB-4, fibrotest, forn index, hepascore, and fibrometer for the diagnosis of histologic fibrosis stage F4.


	AUROC (95% CI)	Cutoff	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Youden	vs. sGDNF value

Primary analysis F0–3 vs. F4
sGDNF	0.78 (0.73–0.82)	28.74	84.85	60.65	18.5	97.4	0.4550
APRI	0.68 (0.63–0.73)	0.41	93.94	38.89	14.2	98.3	0.3283	0.1417
FIB-4	0.71 (0.66–0.76)	1.12	90.91	44.05	14.7	97.9	0.3496	0.3216
Fibrotest	0.70 (0.65–0.75)	0.89	63.64	70.10	18.4	94.8	0.3373	0.1998
Forn index	0.73 (0.68–0.78)	3.94	93.94	40.19	14.3	98.4	0.3413	0.4837
Hepascore	0.67 (0.62–0.72)	0.80	75.76	59.16	16.4	95.8	0.3492	0.1234
Fibrometer	0.69 (0.64–0.74)	2.54	75.76	56.91	15.7	95.7	0.3267	0.1856

Second analysis F3 vs. F4
sGDNF	0.74 (0.65–0.83)	33.43	63.64	83.58	65.6	82.4	0.4722
APRI	0.55 (0.44–0.65)	0.41	93.94	25.76	38.7	89.5	0.1970	0.0124
FIB-4	0.55 (0.44–0.65)	2.20	57.57	61.19	42.2	74.5	0.1877	0.0181
Fibrotest	0.61 (0.50–0.70)	0.89	63.64	59.70	43.8	76.9	0.2334	0.0802
Forn index	0.57 (0.47–0.67)	5.45	63.64	50.75	38.9	73.9	0.1438	0.0368
Hepascore	0.55 (0.45–0.65)	0.80	75.76	40.30	38.5	77.1	0.1606	0.0211
Fibrometer	0.53 (0.43–0.64)	1.69	87.88	25.37	36.7	81.0	0.1325	0.0133

AUROC of sGDNF vs. APRI, FIB-4, fibrotest, forn index, hepascore, fibrometer via DeLong test. NPV, negative predictive value; PPV, positive predictive value; Se, sensitivity; Sp, specificity. APRI, aspartate transaminase-platelet ratio index; FIB-4, fibrosis-4 index; APRI: (AST (U/L)/upper normal limit) × 100/platelets (10⁹/L). FIB-4 index: age (years) × AST (U/L)/(PLT (10⁹/L)) × (ALT (U/L)^1/2). Fibrometer: −0.007 PLT (G/L) − 0.049 PI (%) + 0.012AST (U/L) + 0.005 α2M (mg/dL) + 0.021HA (μg/L) − 0.270 urea (mmol/L) + 0.027 age (yr) + 3.718. Forn index: 7.811 − 3.131 × ln (PLT (10⁹/L)) + 0.781 × ln (GGT (U/L)) + 3.467 × ln (age) − 0.014 × (cholesterol (mg/dl). Hepascore: y = exp (4.185818 − (0.0249 × age) + (0.7464 × sex) + (1.0039 × α2M g/L) + (0.0302 × HA μg/L) + (0.0691 × bilirubin μmol/L) − (0.0012 × GGT U/L)), male = 1, female = 0. Fibrotest: 4.467 × log (α2M (mg/dL)) − 1.357 × log Hap (g/L) + 1.017 log GGT (U/L) + 0.0281 × age + 1.737 × log TBil (μmol/L) − 1.184 × apoA-I (g/L) + 0.301 × (sex) − 5.540, male = 1, female = 0.