Biologic Agents in Crohn’s Patients Reduce CD4⁺ T Cells Activation and Are Inversely Related to Treg Cells

Figure 2

Characteristics of memory and effector markers on CD4⁺ T cells. Green plots healthy individuals and red triangles represent Crohn’s patients undergoing biological therapy. (a) Percentage of CD4⁺ T cells expressing CD45RO⁺. (b) Median fluorescence intensity (MFI) of CD4⁺ T cells expressing CD45RO⁺. (c) Percentage of CD4⁺ T cells expressing RORγt⁺. (d) Median fluorescence intensity (MFI) of CD4⁺ T cells expressing RORgt+. Each dot represents an individual, and bars indicate medians in the graphs. Statistical analysis was performed using the Kruskal–Wallis test.

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