Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Figure 2

Microscopic pictures of the liver sections from different groups. Note. (a) Normal control group: rats treated with 2% Tween-80 followed by NS, (b) negative control group: rats received APAP alone, (c) rats received 100 mg/kg CAME, (d) rats received 200 mg/kg CAME, (e) rats received 400 mg/kg CAME, (f) rats received 100 mg/kg CAAE, (g) rats received 200 mg/kg CAAE, (h) rats received 400 mg/kg CAAE, (i) rats received 400 mg/kg CAAF, (j) rats received 400 mg/kg CABF, (k) rats received 400 mg/kg CACF, and (l) positive control group: rats received 100 mg/kg silymarin. Black arrows indicate areas of tissue necrosis and red arrows indicate areas of vacuolar degeneration of varying degree. APAP: acetaminophen, CAAE: aqueous extract of Cordia africana, CAAF: aqueous fraction of Cordia africana, CABF: butanol fraction of Cordia africana, CACF: chloroform fraction of Cordia africana, CAME: 80% methanol extract of Cordia africana, mg/kg: milligram per kilogram, and NS: normal saline.

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