Prognostic Role of Neutrophil to Lymphocyte Ratio in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Table 1

General characteristics of included studies.

First author	Year	Country	Design	NASH							Fibrosis							NOS score
				Case		Control		Cut-off point	SEN	SP	Case		Control		Cut-off point	SEN	SP
				N	NLR	N	NLR				N	NLR	N	NLR
Alkhouri [6]	2011	USA		50	2.56 ± 1.06	51	1.60 ± 0.61	1.90	72	70	22	2.93 ± 1.49	26	1.73 ± 0.79	2.30	73	77	8
Abdel-razik [5]	2015	Egypt		120	2.60 ± 1.10	753	1.90 ± 0.70	2.05	73	75	57	2.50 ± 1.10	60	1.80 ± 0.90	2.40	69	79	8
Kara [11]	2015	Turkey	R	179	1.71 ± 0.59	47	1.77 ± 0.58	—	—	—	133	1.76 ± 0.64	93	1.86 ± 0.68	—	—	—	7
Mohamed [15]	2015	Egypt		30	2.19 ± 0.60	30	1.55 ± 0.36	1.63	77	87	—	—	—	—	—	—	—	6
Yilmaz [17]	2015	Turkey	R	—	—	—	—	—	—	—	9	5.70 ± 0.83	29	2.52 ± 0.86	—	—	—	6
Asil [7]	2016	Turkey	P	15	2.16 ± 0.49	65	1.62 ± 0.43	1.79	87	81	—	—	—	—	—	—	—	7
Kahraman [10]	2016	Turkey		105	2.12 ± 1.02	38	1.56 ± 0.38	—	—	—	—	—	—	—	—	—	—	7
Chen [8]	2019	China		22	2.04 ± 0.86	25	1.83 ± 0.66	—	—	—	—	—	—	—	—	—	—	6
Hanafy [9]	2019	Egypt		201	2.88 ± 0.44	71	1.80 ± 0.50	—	—	—	—	—	—	—	—	—	—	8
Khoury [12]	2019	Israel	R	52	9.70 ± 5.30	39	6.00 ± 3.90	6.60	77	64	56	10.20 ± 4.40	35	4.90 ± 4.40	5.80	88	80	7
Adithya [14]	2021	Indonesia		70	2.19 ± 0.53	36	1.49 ± 0.30	1.77	82	81	26	2.61 ± 0.51	80	1.74 ± 0.41	2.15	92	88	7
Lauszus [13]	2021	UK		6	1.72 ± 0.41	14	1.40 ± 0.38	—	—	—	—	—	—	—	—	—	—	6
Jayachandra [16]	2021	India		43	3.79 ± 1.81	7	2.41 ± 0.79	—	—	—	13	3.27 ± 0.50	13	1.46 ± 0.51	—	—	—	6

NASH = nonalcoholic steatohepatitis; N = number; NLR = neutrophil to lymphocyte ratio; NOS = the Newcastle–Ottawa Quality Assessment Scale; R = retrospective; : prospective; SEN = sensitivity; SP = specificity.