Research Article

ERCP-Related Adverse Events in Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis

Table 3

Characteristics of ERCP.

Precut n (%)Biliary stent insertion n (%)Pancreatic stent insertion n (%)Biliary sphincterotomy n (%)Pancreatic sphincterotomy n (%)Contrast injection into pancreatic duct n (%)Accidental pass into pancreatic duct n (%)Endoscopist experienceProphylactic antibiotics (%)

Adler (2016)274 (50.9%)8 (1.5%)87 (16.2%)Experienced interventional endoscopistsPeriprocedural (100%)
Alkhatib (2011)70 (38%)76 (41%)Intraprocedural (77%)
Postprocedural for 3–7 days (100%)
Baluyut (2001)33 (52%)Sphincterotomy NOS: 40 (63%)Pre- and postprocedural (100%)
Bangarulingam (2009)PSC: 42 (25%)
Non-PSC: 265 (27%)
PSC: 3 (2%)
Non-PSC: 129 (13%)
Sphincterotomy NOS
PSC: 42 (25%)
Non-PSC: 569 (58%)
PSC: Preprocedural (100%)
Non-PSC: N/A
Cazzagon (2019)
Enns (2003)29 (19.6%)
Etzel (2008)PSC: 51 (60.0%)
Non-PSC: 60 (85.7%)
PSC: Preprocedural (98.8%) and postprocedural (89.4%)
Non-PSC: Preprocedural (95.7%) and postprocedural (58.6%)
Gluck (2008)43 (51%)64 (60.4%)Intraprocedural (100%)
Gotthardt (2010)5 (5.2%)Performed by an experienced physicianPeriprocedural (100%)
Ismail (2012)9 (2.0%)176 (39.9%)4 (0.91%)15 (3.4%)129 (29.3%)Expert endoscopistPreprocedural (100%)
Kaya (2001)Balloon dilation: 0 (0%)
Balloon dilation and stenting: 14 (100%)
Balloon dilation alone: Preprocedural (100%) and postprocedural (64.7%)
Balloon dilation and stenting: Preprocedural (100%) and postprocedural (51.4%)
Koskensalo (2020)Diclofenac: 8 (0.8%)
No diclofenac: 0 (0%)
Diclofenac: 1 (0.1%)
No diclofenac: 0 (0%)
Diclofenac: 215 (21.5%)
No diclofenac: 409 (40.9%)
Diclofenac: 90 (9%)
No diclofenac: 142 (14.2)
Diclofenac: Preprocedural (100%)
No diclofenac: Preprocedural (100%)
Navaneethan (2015)19 (2.9%)244 (37.1%)31 (10.5%)3 (1.0%)7 (9.1%)32 (4.9%)Experienced interventional endoscopistsIntraprocedural (100%)
Navaneethan (2017)Group 1 (control): 11 (7.1%)
Group 2 (bile aspiration before contrast injection): 2 (4.4%)
Group 1: 83 (53.2%)
Group 2: 0 (0%)
Group 1: 4 (2.6%)
Group 2: 11 (23.9%)
Group 1: 4 (2.6%)
Group 2: 2 (4.4%)
Group 1: 27 (17.3%)
Group 2: 5 (10.9%)
Group 1: 15 (9.6%)
Group 2: 2 (4.4%)
Experienced interventional endoscopists with a minimum of 1000 ERCPs prior to the study and an annual average of 400 ERCPsGroup 1: intraprocedural (100%) and postprocedural for 5 days (100%)
Group 2: N/A
Parlak (2004)8 (13.8%)Sphincterotomy NOS: 37 (100%)
Peiseler (2018)69 (10.4%)116 (17%)Experienced endoscopistIntraprocedural and postprocedural for 2 days (96%)
Ponsioen (2018)34 (52.3%)24 (36.9)
Rupp (2019)Sphincterotomy NOS: 286 (100%)Experienced endoscopistsProphylactic antibiotics (100%)
Thiruvengadam (2016)Endoscopists ranged in experience
Von Seth (2015)PSC: 15 (11%)
Non-PSC: 756 (9%)
PSC: 38 (27%)
Non-PSC: 3226 (37%)
PSC: 2 (1.4%)
Non-PSC: 63 (0.6%)
Sphincterotomy NOS:
PSC: 50 (35%)
Non-PSC: 5554 (63%)
PSC: 44 (31%)
Non-PSC: 2472 (28%)
PSC: prophylactic (49%)
Non-PSC: prophylactic (36%)

N/A, not available; NOS, not otherwise specified.