Polyethylene Glycol 3350 in the Treatment of Chronic Idiopathic Constipation: Post hoc Analysis Using FDA Endpoints

Table 2

Change in BM-related symptoms per week over the 24-week study period.

BM-related symptom	Mean (SD) weekly change from baseline		P value
	PEG 3350 (N = 204)	Placebo (N = 100)
Hard/lumpy^†	–2.1 (3.06)	–0.9 (2.49)	0.0014
Straining^†	–1.4 (3.63)	–0.8 (2.38)	0.0799
Cramping^‡	–0.3 (0.62)	–0.1 (0.59)	0.0272
Gas^‡	–0.1 (0.78)	–0.1 (0.62)	0.5949

Abbreviations: BM, bowel movement; PEG, polyethylene glycol; SD, standard deviation. †Mean change in the number of BMs/week with symptom. ‡Mean change in subject-assessed symptom score (0–4 scale).