Misconceptions Drive COVID-19 Vaccine Hesistancy in Individuals with Inflammatory Bowel Disease

Table 2

Factors associated with vaccine uptake.

Factor	Univariate OR (95% confidence interval)	Multivariate OR (95% confidence interval)
Male sex	0.71 (0.30 – 1.65)
University or vocational degree	2.76 (1.29 – 5.91),	2.03 (0.77 – 5.29),
Crohn’s disease	1.24 (0.54 – 2.84),
Current biologic or small molecule	1.09 (0.52 – 2.29),
Current thiopurine or methotrexate	1.04 (0.49 – 2.19),
Combination anti-TNF and immunomodulator use	0.75 (0.30 – 1.91),
Influenza vaccination in past 12 months	4.64 (2.12 – 10.15)	3.28 (1.34 – 8.9),
Completion of childhood immunisation	2.09 (0.45 – 9.67),
Confidence in safety of vaccines in general	6.87 (2.90 – 16.26),	2.16 (0.73 – 6.37),
Self-perceived risk of being more unwell with COVID-19 infection due to IBD	5.47 (2.47 – 12.12)	5.25 (1.96 – 14.04),
Self-perceived risk of vaccines causing IBD flare	0.25 (0.11 – 0.53),	0.28 (0.0.10 – 0.77),
Concern that IBD medications will reduce vaccine efficacy	1.63 (0.75 – 3.55),
Concern that vaccination will reduce fertility	0.34 (0.10 – 1.08),	0.57 (0.13 – 1.00),
Concern that vaccines are not safe in pregnancy	0.08(0.03 – 0.19),	0.22 (0.8 – 0.65),

Denotes significance .