Antiviral Therapy for a Postpartum Flare in Women with Chronic HBV Infection Shortens the ALT Recovery Time and Reduces Hepatitis Re-Flare Rates within 4 years
Table 1
Baeseline characteristics of PT-G and NPT-G.
Baeseline characteristics
Group 1: NPT-G (n = 49) M (P25, P75)
Group 2: PT-G (n = 103) M (P25, P75)
t/Z/x2
Age (years)
28 (26, 30.5)
29 (27, 32)
1.545
0.122
BMI (kg/m2)
23.91 (21.94, 26.02)
24.84 (23.05, 26.95)
1.592
0.114
WBC (×109/L)
8.60 (7.45, 9.70)
8.91 (7.89, 9.90)
1.330
0.184
HGB (g/L)
118 (112, 125)
121 (113, 126)
1.325
0.185
PLT (×109/L)
194.00 (170.00, 228.00)
197.50 (171.75, 226.75)
0.427
0.669
ALT (U/L)
18.50 (14.50, 23.00)
19.50 (14.20, 25.70)
0.320
0.749
AST (U/L)
18 (17.10, 22.00)
19.10 (15.90, 7.90)
0.144
0.886
TBIL (umol/L)
6.50 (5.40, 7.90)
6.00 (5.20, 7.90)
−0.904
0.336
DBIL (umol/L)
1.50 (1.10, 1.90)
1.40 (1.10, 1.80)
−0.729
0.466
ALB (g/L)
38.20 (1325.80, 1706.70)
37.00 (35.30, 38.70)
−2.974
0.003
HBeAg (S/CO)
1509.60 (1325.80, 1706.70)
1543.16 (1376.86, 1696.36)
0.394
0.693
HBcAb (S/CO)
9.89 (8.47, 10.99)
9.71 (8.78, 10.49)
−0.224
0.823
HBV DNA (log IU/mL)
Baseline
8.23 (7.68, 8.23)
8.23 (7.94, 8.23)
−0.650
0.516
Intrapartum
8.20 (7.38, 8.23)
3.81 (3.36, 4.54)
HBV DNA median fall
0.08 (0.00, 0.48)
4.08 (3.52, 4.58)
8.687
Parity
1.541
0.214
Primiparity
n = 19 (38.78%)
n = 51 (49.51%)
multiparity
n = 30 (61.22%)
n = 52 (50.49%)
Type of anti-HBV therapy
Telbivudine
n = 96 (93.20%)
Tenofovir
n = 7 (6.80%)
Postpartum hepatitis flare
37 (75%)
71 (69%)
No postpartum hepatitis flare
12 (24%)
32 (31%)
ALT recovery time (postpartum hepatitis flare women)
≤12 w
4 (11.1%)
23 (34.8%)
x2 = 5.579
0.018
>12 w
32 (88.8%)
43 (65.2%)
≤26 w
16 (44.4%)
44 (66.7%)
x2 = 4.749
0.029
>26 w
20 (55.6%)
22 (33.3%)
ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBil, total bilirubin; DBIL, direct bilirubin; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HBV DNA, hepatitis B deoxyribonucleic acid; SD, standard deviation; ULN, upper limit of normal; WBC, white blood cell; PLT, platelet; HGB, hemoglobin; ALB, albumin.
