Antiviral Therapy for a Postpartum Flare in Women with Chronic HBV Infection Shortens the ALT Recovery Time and Reduces Hepatitis Re-Flare Rates within 4 years
Table 2
Comparison between AT-G and NAT-G.
intrapartum characteristics
NAT-G (n = 65) n (%), M (P25, P75)
AT-G (n = 38) n (%), M (P25, P75)
Z/x2
Age (years)
29 (26, 31.5)
30 (27, 31.5)
Z = 0.576
0.564
WBC (×109/L)
8.49 (6.84, 9.83)
7.86 (6.92, 9.88)
Z = 0.277
0.782
HGB (g/L)
126 (118, 133)
124 (112, 132.25)
Z = 0.523
0.601
PLT (×109/L)
188 (167.5, 223.5)
178 (155.25, 208.75)
Z = −1.517
0.129
ALT (U/L)
17.7 (13.03, 26.45)
20.75 (14.55, 28.48)
Z = 1.267
0.205
ALT (U/L) PP 6 w
62.7 (45.23, 126.05)
89.5 (59.88, 174.93)
Z = 1.864
0.062
ALT (U/L) PP 12 w
51.1 (35.1, 78.13)
61.3 (28.7, 117.4)
Z = 1.056
0.291
AST (U/L)
20 (16.8, 26.15)
21.15 (17.55, 28.280
Z = 1.28
0.200
TBIL (umol/L)
7.2 (5.63, 8.4)
6.85 (5.23, 8.73)
Z = 0.699
0.484
DBIL (umol/L)
1.5 (1.2, 2.1)
1.65 (1.28, 2.03)
Z = 0.926
0.355
ALB (g/L)
37 (34.7, 38.28)
34.9 (32.72, 37.13)
Z = 3.268
0.001
HBeAg (S/CO)
1510.53 (1304.9, 1633.23)
1517.88 (1184.97, 1633.35)
Z = 0.199
0.842
HBcAb (S/CO)
9.86 (8.58, 10.52)
10.12 (9.17, 10.70)
Z = 0.806
0.421
HBV DNA (log IU/mL)
4.46 (3.81, 7.60)
4.27 (3.40, 7.36)
Z = −0.914
0.361
ALT recovery time
≤12 week
14 (23.0%)
16 (42.1%)
x2 = 4.067
0.044
>12 week
47 (77.0%)
22 (57.9%)
≤26 week
35 (57.3%)
32 (84.2%)
x2 = 7.707
0.006
>26 week
26 (42.6%)
6 (15.8%)
ALT re-flare within 4 years
Re-flare (ALT-RF)
24 (45.4%)
3 (9.68%)
x2 = 14.003
≤0.001
No re-flare (ALT-NRF)
20 (54.6%)
28 (90.32%)
PP 6 w, postpartum 6 weeks; PP 12 w, postpartum 12 weeks; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBil, total bilirubin; DBIL, direct bilirubin; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HBV DNA, hepatitis B deoxyribonucleic acid; SD, standard deviation; WBC, white blood cell; PLT, platelet; HGB, hemoglobin.
