Combined Liver Stiffness and Α-fetoprotein Further beyond the Sustained Virologic Response Visit as Predictors of Long-Term Liver-Related Events in Patients with Chronic Hepatitis C

Figure 3

Kaplan–Meier survival analysis for predicting LREs from the baseline of Y3 post-SVR. (a) LREs (n = 15), stratified by clinical cirrhosis (TW0); (b) LREs (n = 14), stratified by LS (Y3PSVR); (c) LREs (n = 13, stratified by AFP (Y3PSVR); (d) LREs (n = 12), stratified by concurrent LS and AFP (Y3PSVR), pairwise log-rank ’s were significant only in classes “AFP ≥3.00 and LS ≥1.45” versus “AFP <3.00 and LS <1.45” (), and “AFP ≥3.00 and LS ≥1.45” versus “AFP ≥3.00 and LS <1.45” (); (e) LREs (n = 12), stratified by concurrent LS and AFP (Y3PSVR); (f) LREs (n = 2), stratified and validated among patients with cirrhosis (n = 63, at baseline); (g) LREs (n = 13), stratified and validated among patients without cirrhosis (n = 457, at baseline). Participants with missing data of LS (Y3PSVR) or AFP (Y3PSVR) were excluded from the analysis. AFP, α-fetoprotein (ng/mL); LRE, liver-related event; LS, liver stiffness (m/s); SVR, sustained virologic response (visit); TW0, treatment baseline; Y3PSVR, year 3 post-sustained virologic response.

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