Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients
Table 1
Basal characteristics of the patients according to disease severity.
Characteristics
Nonsevere (N = 79)
Severe (N = 33)
Fulminant (N = 14)
value
Age, years
50.6 ± 14.5
45.0 ± 16.5
49.1 ± 15.8
0.213
Female sex
60 (76.0%)
24 (73.0%)
13 (93.0%)
0.337
Autoimmune comorbidities
19 (24.0%)
9 (27.0%)
1 (7.0%)
0.337
Hypothyroidism
12 (15.0%)
6 (18.0%)
1 (7.0%)
0.756
Sjögren disease
4 (5.0%)
4 (12.0%)
0 (0.0%)
0.271
TP (idiopathic)
2 (3.0%)
0 (0.0%)
0 (0.0%)
—
Ulcerative colitis
1 (1.0%)
1 (3.0%)
0 (0.0%)
—
Others
3 (4.0%)
0 (0.0%)
0 (0.0%)
—
Total bilirubin—(mg/dL)
6.0 (1.7–11.9)
15.3 (9.0–22.3)
20.6 (15.5–28.8)
<0.001
AST—(U/L)
1016 (635–1381)
1240 (948–1864)
1094 (664–2000)
0.050
ALT—(U/L)
1227 (818–1818)
1178 (775–1478)
902 (602–2102)
0.649
AP—(U/L)
209 (156–283)
231 (191–313)
273 (186–498)
0.075
GGT—(U/L)
295 (189–429)
216 (155–347)
174 (112–478)
0.154
Prothrombin %
74.3 ± 12.9
42.3 ± 6.4
30.9 ± 13.1
<0.001
ANA > 1 : 40
60 (76.0%)
23 (70.0%)
10 (71.0%)
0.753
SMA > 1 : 40
38 (48.0%)
15 (45.0%)
7 (50.0%)
0.965
AMA (above normal)
4 (5.0%)
2 (6.0%)
0 (0.0%)
1.000
Immunoglobulin G
Above normal
57 (72.2%)
24 (72.7%)
7 (50.0%)
0.435
No data
3 (3.8%)
1 (3.0%)
1 (7.1%)
Anti-LKM1
Above normal
4 (5.0%)
0 (0.0%)
0 (0.0%)
0.170
No data
2 (1.6%)
2 (1.7%)
0 (0.0%)
Corticosteroids use
78 (99.0%)
33 (100.0%)
8 (57.0%)
<0.001
Combined outcome
0 (0.0%)
0 (0.0%)
10 (71.4%)
<0.001
Death
0 (0.0%)
0 (0.0%)
4 (28.6%)
<0.001
Liver transplant
0 (0.0%)
0 (0.0%)
9 (64.3%)
<0.001
Numerical data are presented as the mean ± DS or median (IQR) depending on their distribution. LT: liver transplant; AST: aspartate aminotransferase; ALT: alanine aminotransferase; AP: alkaline phosphatase; GGT: gamma-glutamyl transferase; ANA: antinuclear antibody; SMA: smooth muscle antibody; AMA: antimitochondrial antibody; anti-LKM1: anti-liver-kidney microsome antibodies.
