Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients
Table 2
Basal characteristics of the patients with acute autoimmune hepatitis.
Characteristics
Total (N = 126)
No Death/LT (N = 116)
In-hospital Death/LT (N = 10)
value
Age, years
49.0 ± 15.3
48.4 ± 15.4
55.7 ± 12.0
0.150
Female sex (%)
97 (77.0%)
88 (75.9%)
9 (90.0%)
0.452
Autoimmune comorbidities (%)
29 (23.0%)
28 (24.1%)
1 (10.0%)
0.452
Hypothyroidism
19 (15.1%)
18 (15.5%)
1 (10.0%)
—
Sjögren disease
8 (6.4%)
8 (6.9%)
0 (0.0%)
—
TP (idiopathic)
2 (1.6%)
2 (1.7%)
0 (0.0%)
—
Ulcerative colitis
2 (1.6%)
2 (1.7%)
0 (0.0%)
—
Others
3 (2.4%)
3 (2.6%)
0 (0.0%)
—
Total bilirubin—(mg/dL)
10.0 (3.4–17.9)
8.6 (3.0–15.8)
20.0 (15.5–28.8)
<0.001
AST—(U/L)
1042 (678–1469)
1042 (685–1461)
958 (664–2000)
0.935
ALT—(U/L)
1171 (768–1740)
1201 (797–1738)
815 (602–3000)
0.542
AP—(U/L)
216 (169–310)
215 (168–298)
273 (212–594)
0.127
GGT—(U/L)
270.0 (159–406)
269 (160–389)
317 (119–510)
0.815
Prothrombin %
61.1 ± 20.9
63.4 ± 19.7
33.7 ± 14.3
<0.001
ANA > 1 : 40 (%)
93 (73.8%)
86 (74.1%)
7 (70.0%)
0.721
SMA > 1 : 40 (%)
60 (47.6%)
55 (47.4%)
5 (50.0%)
1.000
AMA (above normal) (%)
6 (4.8%)
6 (5.2%)
0 (0.0%)
—
Immunoglobulin G (%)
Above normal
88 (69.8%)
84 (72.4%)
4 (40.0%)
0.069
No data
5 (4.0%)
4 (3.5%)
1 (10.0%)
Anti-LKM1 (%)
Above normal
4 (3.2%)
4 (3.5%)
0 (0.0%)
—
No data
2 (1.6%)
2 (1.7%)
0 (0.0%)
Disease severity (%)
Nonsevere
79 (62.7%)
79 (68.1%)
0 (0.0%)
<0.001
Severe
33 (26.2%)
33 (28.4%)
0 (0.0%)
Fulminant
14 (11.1%)
4 (3.4%)
10 (100.0%)
Corticosteroids use (%)
119 (94.4%)
113 (97.4%)
6 (60.0%)
<0.001
Numerical data are presented as the mean ± DS or median (IQR) depending on their distribution. LT: liver transplant; AST: aspartate aminotransferase; ALT: alanine aminotransferase; AP: alkaline phosphatase; GGT: gamma-glutamyl transferase; ANA: antinuclear antibody; SMA: smooth muscle antibody, AMA: antimitochondrial antibody; anti-LKM1: anti-liver-kidney microsome antibodies.
