Research Article
Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients
Table 3
Histological findings from liver biopsies of acute autoimmune hepatitis patients.
| | Histological finding | Total (N = 126) | No Death/LT (N = 116) | In-hospital Death/LT (N = 10) | value |
| | Interface hepatitis | 103 (81.7%) | 96 (82.8%) | 7 (70%) | 0.388 | | Plasma cells | 109 (86.5%) | 100 (86.2%) | 9 (90.0%) | 1.000 | | Chronic hepatitis | 102 (81.0%) | 95 (81.9%) | 7 (70.0%) | 0.401 | | Rosettes | 45 (35.7%) | 42 (36.2%) | 3 (30.0%) | 1.000 | | Cholestasis | 52 (41.3%) | 42 (36.2%) | 10 (100.0%) | <0.001 | | Centrilobular necrosis | | Mild | 51 (40.5%) | 48 (41.4%) | 3 (30.0%) | 0.119 | | Moderate | 23 (18.3%) | 23 (19.8%) | 0 (0.0%) | | Severe | 52 (41.3%) | 45 (38.8%) | 7 (70.0%) | | Fibrosis (METAVIR) | 1 (0–3) | 1 (0–3) | 1 (0–3) | 0.831 | | Mod/Severe† | 34 (27.0%) | 31 (26.7%) | 3 (30.0%) | 1.000 |
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†: Moderate/severe fibrosis is defined as a METAVIR score of F3 or F4.
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