Research Article
Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients
Table 6
Histological findings from liver biopsies according to disease severity.
| | Histological finding | Nonsevere (N = 79) | Severe (N = 33) | Fulminant (N = 14) | value |
| | Interface hepatitis | 67 (85.0%) | 25 (76.0%) | 11 (79.0%) | 0.424 | | Plasma cells | 70 (89.0%) | 26 (79.0%) | 13 (93.0%) | 0.388 | | Chronic hepatitis | 66 (84.0%) | 25 (76.0%) | 11 (79.0%) | 0.625 | | Rosettes | 27 (34.0%) | 15 (45.0%) | 3 (21.0%) | 0.297 | | Cholestasis | 23 (29.0%) | 16 (48.0%) | 13 (93.0%) | <0.001 | | Centrilobular necrosis | | Mild | 39 (49.0%) | 7 (21.0%) | 5 (36.0%) | <0.001 | | Moderate | 19 (24.0%) | 4 (12.0%) | 0 (0.0%) | | Severe | 21 (27.0%) | 22 (67.0%) | 9 (64.0%) | | Fibrosis (METAVIR) | 1 (0–3) | 1 (0–3) | 1 (0–3) | 1.000 | | Mod/Severe† | 21 (27.0%) | 9 (27.0%) | 4 (29.0%) | 1.000 |
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†: Moderate/severe fibrosis is defined as a METAVIR score of F3 or F4.
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