Virulence Genes of Helicobacter pylori Increase the Risk of Premalignant Gastric Lesions in a Colombian Population

Table 5

Measures of association of vacA and cagA bacterial genotypes.

		Nonatrophic gastritis	Precursors lesions of gastric malignancy	OR	IC 95%	value
vacA	s2m2	28 (14.9)	15 (5.7)	1	1	1
	s1m1	136 (72.3)	222 (84)	3.05	(1.57–5.91)	0.001
	s1m2	2 (1.1)	7 (2.7)	6.53	(1.2–35.48)	0.03
	Coinfection^‡	22 (11.7)	20 (7.6)	1.69	(0.71–4.06)	0.234
cagA	cagA−	116 (61.7)	145 (54.9)	1	1	1
	cagA+	72 (38.3)	119 (45.1)	1.32	(0.903–1.94)	0.151

Patients with atrophy, intestinal metaplasia, dysplasia, were added to one category. ^‡Coinfection: s1s2m1, s1s2m2, s1m1m2, s2m1m2, s1s2m1m2. A value of <0.05 was considered statistically significant.