Virulence Genes of Helicobacter pylori Increase the Risk of Premalignant Gastric Lesions in a Colombian Population

Table 6

Multivariate logistic regression model showing measures of association between the variables of interest and outcome (precursor lesions of gastric malignancy).

Variable	Crude		-value	Adjusted^a		-value	Adjusted^b		-value
	OR	95%CI		OR	95%CI		OR	95%CI
Age
46–60 years	4.35	(2.79–6.79)	0.001	3.85	(2.38–6.23)	0.001	4.91	(3.09–7.78)	0.001
≥61 years	16.32	(8.08–32.95)	0.001	11.85	(5.65–24.85)	0.001	17.09	(8.35–34.99)	0.001
Education level
Elementary school	7.02	(4.07–12.12)	0.001	3.36	(1.83–6.16)	0.001	NA^§	NA	NA
Middle school	2.9	(1.6–5.26)	0.001	2.26	(1.18–4.31)	0.013	NA	NA	NA
Genotypes
VacA/s1m1	3.05	(1.57–5.91)	0.001	3.68	(1.73–7.82)	0.001	3.94	(1.88–8.23)	0.001
VacA/s1m2	6.53	(1.2–35.48)	0.03	5.86	(0.905–38.01)	0.064	7.53	(1.11–50.88)	0.038
Coinfection^‡	1.69	(0.71–4.06)	0.234	1.98	(0.73–5.35)	0.178	1.97	(0.74–5.19)	0.173

a: adjusted for categorized age, bacterial genotype, and education level; b: adjusted for age and bacterial genotype. ^§NA: not applicable. ^‡Coinfection: s1s2m1, s1s2m2, s1m1m2, s2m1m2, s1s2m1m2. A -value of <0.05 was considered statistically significant.