qHBsAg for the Identification of Liver Histological Abnormalities in HBeAg-Negative Chronic Hepatitis B Patients with Normal and Mildly Elevated ALT Levels

Table 2

Multivariate analysis of clinical parameters independently associated with significant histological abnormalities.

Parameter	Necroinflammation ≥ G2			Fibrosis ≥ S2			Necroinflammation ≥ G2 or fibrosis ≥ S2
	OR	95% CI	value	OR	95% CI	value	OR	95% CI	value
HBsAg	1.634	1.274–2.097	<0.0001	1.299	1.031–1.637	0.026	1.493	1.157–1.927	0.002
AST	1.048	1.018–1.079	0.002	1.039	1.014–1.065	0.002	1.057	1.023–1.093	0.001
Age	1.027	1.002–1.053	0.031
HBV family history				1.725	1.123–2.650	0.013	1.877	1.117–3.153	0.017

AST, aspartate transaminase.