qHBsAg for the Identification of Liver Histological Abnormalities in HBeAg-Negative Chronic Hepatitis B Patients with Normal and Mildly Elevated ALT Levels

Table 3

Predictive values for serum levels of HBsAg, AST, and age for identifying significant histological changes in HBeAg-negative patients (n = 392).

		G2 or S2 (ALT ≤80 IU/L)
		Yes	NO	PPV (%)	Sensitivity (%)	NPV (%)	Specificity (%)
HBsAg ≥1000 IU/ml	YES	199	37	84.3	65.3	32.1	57.5
	NO	106	50
Age >40 years	YES	174	42	80.6	57.1	25.6	51.7
	NO	131	45
AST >25 IU/L	YES	195	36	84.4	63.9	31.7	58.6
	NO	110	51
HBsAg ≥1000 IU/ml and age >40 years and ALT >25 IU/L	YES	70	6	92.1	23.0	25.6	93.1
	NO	235	81

PPV, positive predictive value; NPV, negative predictive value.