Canadian Journal of Gastroenterology and Hepatology

Acute-on-Chronic Liver Failure: From Basic Research to Clinical Applications


Status
Published

Lead Editor

1West China Hospital of Sichuan University, Chengdu, China

2Kanazawa University Hospital, Kanazawa, Japan

3Qilu Hospital of Shandong University, Jinan, China

4University of Padova, Padova, Italy


Acute-on-Chronic Liver Failure: From Basic Research to Clinical Applications

Description

Despite the availability of potent vaccines, hepatitis B virus (HBV) infection remains a major public health problem worldwide with approximately 240 million individuals chronically infected, and 20% of those chronically infected patients would progress to life-threatening complications. Acute-on-chronic liver failure (ACLF) is a critical complication of chronic hepatitis B (CHB), and it can develop at any stage in the progression of CHB. Additionally, many noninfectious chronic liver diseases (such as alcoholic cirrhosis, nonalcoholic fatty liver diseases, and autoimmune liver diseases) also could develop to ACLF. In the coming decade, ACLF may be still a common severe liver disease in clinical practice.

Stopping or slowing the progression of chronic liver diseases to ACLF at an early stage should be the most effective way to reduce the morbidity and mortality of ACLF. The studies on molecular pathogenesis, ideal early-warning, and prognostic prediction system of ACLF not only will greatly improve the prevention and early diagnosis but also are very helpful to develop new targets and strategies for treatment.

We invite authors to contribute original research articles as well as review articles that will provide the information on the following topics.

Potential topics include but are not limited to the following:

  • ACLF around the world: epidemiological and clinical aspects
  • Molecular mechanisms of ACLF
  • Prognostic evaluation of ACLF
  • Novel strategies for treating ACLF, including artificial liver support system and stem cell transplantation

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5029789
  • - Editorial

Acute-on-Chronic Liver Failure: From Basic Research to Clinical Applications

En-Qiang Chen | Tetsuro Shimakami | ... | Paolo Angeli
  • Special Issue
  • - Volume 2018
  • - Article ID 1579508
  • - Research Article

Management Strategies and Outcomes for Hyponatremia in Cirrhosis in the Hyponatremia Registry

Samuel H. Sigal | Alpesh Amin | ... | Arun Sanyal
  • Special Issue
  • - Volume 2018
  • - Article ID 1027152
  • - Review Article

Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough

Wim Laleman | Joan Claria | ... | Jonel Trebicka
  • Special Issue
  • - Volume 2018
  • - Article ID 6348948
  • - Research Article

The Correlation between miR-122 and Lipoprotein Lipase Expression in Chronic Hepatitis C Patients

Malgorzata Sidorkiewicz | Martyna Grek-Kowalinska | Anna Piekarska
  • Special Issue
  • - Volume 2018
  • - Article ID 2586052
  • - Research Article

Serum Metabonomics Analysis of Liver Failure Treated by Nonbioartificial Liver Support Systems

Chunyan Wu | Ying Zhu | Mengqian Yu
  • Special Issue
  • - Volume 2018
  • - Article ID 1232785
  • - Research Article

Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure

Xiaoping Wang | Caifei Shen | ... | Weizheng Zeng
  • Special Issue
  • - Volume 2018
  • - Article ID 4909742
  • - Clinical Study

Good Tolerance of Citrate Accumulation due to Plasma Exchange among Patients with Acute-on-Chronic Liver Failure: A Prospective, Observational Study

Yuanji Ma | Yan Xu | ... | Hong Tang
  • Special Issue
  • - Volume 2018
  • - Article ID 2101906
  • - Research Article

Transcriptome Analysis of Porcine PBMCs Reveals the Immune Cascade Response and Gene Ontology Terms Related to Cell Death and Fibrosis in the Progression of Liver Failure

YiMin Zhang | Li Shao | ... | LanJuan Li
  • Special Issue
  • - Volume 2018
  • - Article ID 5108781
  • - Research Article

Bacterial Infection and Predictors of Mortality in Patients with Autoimmune Liver Disease-Associated Acute-On-Chronic Liver Failure

Xuan Zhang | Ping Chen | ... | Lanjuan Li
Canadian Journal of Gastroenterology and Hepatology
 Journal metrics
Acceptance rate26%
Submission to final decision79 days
Acceptance to publication42 days
CiteScore2.800
Impact Factor2.055
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