Canadian Journal of Gastroenterology and Hepatology

Management of Complications of Portal Hypertension

Publishing date
01 May 2019
Submission deadline
11 Jan 2019

1Hospital das Clínicas of Federal University of Minas Gerais, Belo Horizonte, Brazil

2Sorbonne University, Paris, France

3Hospital Português, Salvador, Brazil

Management of Complications of Portal Hypertension


Acute complications of portal hypertension are common conditions and have poor outcomes. In this setting, acute kidney injury is a main predictor of mortality after liver transplantation, and despite progress achieved over last decades, the 6-week mortality associated with variceal bleeding is still in order of 10-20%. Hepatic encephalopthy remains a diagnosis of exclusion and is found in 30–40% of patients with cirrhosis. For these patients, liver transplantation is the unique definitive treatment option.

Recently, the understanding regarding pathogenesis and management of portal hypertension have been improved. However, in acute kidney injury there are no acurate markers to distiguish hepatorrenal syndrome from acute tubular necrosis and in acute bleeding phase of variceal hemohrrage there are no noninvasive markers to predict poor outcomes. In no oesophageal varices bleeding, TIPS and, in special cases, BRTO can be more appropriate solution. In hepatic encephalopathy, increases in brain ammonia, alterations in neurosteroid levels, and neuroinflammation have been identified but there is still a paucity in knowledge of precise pathogenic mechanism and consequently, there is no diagnostic test.

We invite the researchers to contribute original research articles and review articles to explore management, including diagnosis, treatment, and markers of outcomes of acute complications of portal hypertension.

Potential topics include but are not limited to the following:

  • Differential diagnosis between prerenal azotemia (hepatorrenal syndrome) and acute tubular necrosis
  • Use of albumin in acute kidney failure
  • Role of hepatic venous pressure gradient and biomarkers in variceal bleeding
  • Intestinal permeability, damage-associated molecular patterns (DAMPs), and cytokines in acute phase of variceal bleeding
  • Treatment of hepatic encephalopathy
  • TIPS and BRTO in oesophageal and in nonoesophageal varices bleeding
  • The role of portal hypertension in liver resection and liver transplantation


  • Special Issue
  • - Volume 2019
  • - Article ID 6919284
  • - Editorial

Management of Complications of Portal Hypertension

Eduardo Garcia Vilela | Dominique Thabut | ... | Paulo Lisboa Bittencourt
  • Special Issue
  • - Volume 2019
  • - Article ID 6963910
  • - Research Article

High Prevalence of Multidrug Resistant Bacteria in Cirrhotic Patients with Spontaneous Bacterial Peritonitis: Is It Time to Change the Standard Antimicrobial Approach?

Jerônimo De Conto Oliveira | Enrique Carrera | ... | Mario R. Alvares-da-Silva
  • Special Issue
  • - Volume 2019
  • - Article ID 1208614
  • - Research Article

Elective Splenectomy Combined with Modified Hassab’s or Sugiura Procedure for Portal Hypertension in Decompensated Cirrhosis

Ya-wu Zhang | Feng-xian Wei | ... | You-cheng Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 7956717
  • - Review Article

Unsolved Questions in Salvage TIPSS: Practical Modalities for Placement, Alternative Therapeutics, and Long-Term Outcomes

Charlotte Bouzbib | Philippe Sultanik | ... | Marika Rudler
  • Special Issue
  • - Volume 2019
  • - Article ID 6567850
  • - Research Article

Clinical Aspects and Prognosis Evaluation of Cirrhotic Patients Hospitalized with Acute Kidney Injury

Célio Geraldo de Oliveira Gomes | Marcus Vinicius Melo de Andrade | ... | Eduardo Garcia Vilela
  • Special Issue
  • - Volume 2018
  • - Article ID 3541365
  • - Clinical Study

Effect of Admission Time on the Outcomes of Liver Cirrhosis with Acute Upper Gastrointestinal Bleeding: Regular Hours versus Off-Hours Admission

Yingying Li | Bing Han | ... | Xingshun Qi
Canadian Journal of Gastroenterology and Hepatology
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