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Canadian Journal of Infectious Diseases
Volume 2, Issue 1, Pages 5-11
http://dx.doi.org/10.1155/1991/124860
Infection and Immunity Symposium

Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1

Mark A Wainberg,1,3 Ronald Rooke,3 Michel Tremblay,3 XuGuang Li,3 Michael A Parniak,3 Qing Gao,3 Xiao-Jian Yao,3 Chris Tsoukas,2,3 JSG Montaner,1 M Fanning,2 and J Ruedy1

1St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
2Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
3Jewish General Hospital, Montreal General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, Canada

Copyright © 1991 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A number of laboratories have now independently confirmed that zidovudine (AZT)-resistant strains of human immunodeficiency virus type 1 (HIV-1) may be isolated from patients undergoing prolonged therapy with this drug. In certain instances, such drug-resistant viral isolates have been obtained from patients with clinical acquired immune deficiency syndrome (AIDS), while in others, isolation of drug-resistant strains has been achieved in the case of HIV seropositive, asymptomatic subjects. Most of the evidence points to a series of mutations within the polymerase gene of HIV-1, which encodes viral reverse transcriptase, as being responsible for development of the drug-resistant phenotype. It further appears that over 50% of patients treated with AZT for periods longer than six months are likely to yield drug-resistant strains of HIV-1 in their circulation. Furthermore, the development of drug resistance soon after initiation of AZT therapy may potentially be correlated with the likelihood of AZT treatment failure. In several instances, cross resistance has been observed between AZT and other nucleosides being considered for potential therapy of HIV-1-associated disease.