Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 1993 / Article

Case Report | Open Access

Volume 4 |Article ID 576891 | https://doi.org/10.1155/1993/576891

Scott A Halperin, G Robert La Roche, "Long Term Therapy of Cytomegalovirus Retinitis with Ganciclovir in a Child with Acquired Immunodeficiency Syndrome", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 4, Article ID 576891, 6 pages, 1993. https://doi.org/10.1155/1993/576891

Long Term Therapy of Cytomegalovirus Retinitis with Ganciclovir in a Child with Acquired Immunodeficiency Syndrome

Received01 Feb 1991
Accepted28 Oct 1991

Abstract

Cytomegalovirus retinitis is the most severe ophthalmological complication of patients with acquired immune deficiency syndrome (aids). Ganciclovir must be given continuously to control progression of the disease or relapse typically occurs. Data in children are limited; this report describes a nine-year-old boy with transfusion-acquired aids who was treated with ganciclovir for 23 months for control of cytomegalovirus retinitis. The retinal disease was exacerbated when ganciclovir was temporarily withheld because of presumed drug toxicity, and improved with re-institution of therapy. When ganciclovir was finally discontinued because of complete loss of vision, the patient rapidly deteriorated and died; widespread cytomegalovirus infection was found at autopsy. Subcapsular cataracts appearing during therapy were thought to be a toxic effect of ganciclovir. Ganciclovir can be effective in controlling cytomegalovirus retinitis in children; however, similarities in laboratory findings may lead to confusion between systemic drug toxicity and disease progression.

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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