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Canadian Journal of Infectious Diseases
Volume 5, Suppl B, Pages 14B-20B
http://dx.doi.org/10.1155/1994/549025

Advances in the Treatment of Desseminated Mycobacterium avium Complex in Adults with AIDS

Carol A Kemper1,2,3

1Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, USA
2Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, USA
3AIDS Community Research Consortium, Redwood City, California Collaborative Treatment Group, San Diego, California, USA

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although the prospects for successful treatment of Mycobacterium avium complex (MAC) infection in AIDS recently seemed quite dismal, the introduction of the semisynthetic macrolides, clarithromycin and azithromycin, has altered this perspective. Several recent clinical studies have been key to our understanding of the successful management of these patients and are the basis of this review. Yet, some patients with disseminated MAC remain poorly responsive to therapy, intolerance often limits therapy, and recrudescent bacteremia often occurs. Though our understanding of this infection has been rapidly advanced in the past three years. much remains to be learned about its optimal therapeutic management.