Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 1995 / Article

Brief Report | Open Access

Volume 6 |Article ID 458762 | https://doi.org/10.1155/1995/458762

Donald E Low, The Canadian Antimicrobial Resistance Study Group, "Comparative Activity of Cefepime with Several Antimicrobials against Aerobic Gram-Negative and Gram-Positive Organisms Isolated from Patients across Canada in 1993", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 6, Article ID 458762, 5 pages, 1995. https://doi.org/10.1155/1995/458762

Comparative Activity of Cefepime with Several Antimicrobials against Aerobic Gram-Negative and Gram-Positive Organisms Isolated from Patients across Canada in 1993

Abstract

To compare the activity of cefepime, a fourth-generation cephalosporin, with several available antimicrobials, in vitro susceptibility studies were carried out on bacteria commonly associated with various infections, including sepsis. Ten tertiary care hospital laboratories in six provinces provided 1276 clinically relevant isolates of aerobic Gram-negative bacilli and Gram-positive cocci during 1993. When the activity of each of the antimicrobials was determined against all isolates submitted, cefepime, piperacillin/tazobactam, imipenem and ciprofloxacin all had minimal inhibitory concentrations for 90% of the organisms (mic90) two or more dilutions below the mic resistant category. Gentamicin’s mic90 against all organisms tested was one dilution below the mic resistant category. The mic90s of the third-generation cephalosporins, piperacillin and ticarcillin/clavulanate, for Enterobacter species fell in the resistant category. This is presumably due to constitutive high level chromosomal cephalosporinase production. The mic90s of cefepime for Enterobacter species was three or more dilutions below the mic resistant category. The mic90s of all antimcrobials against Staphylococcus aureus, with the exception of ceftazidime and piperacillin, had mic90 categories two or more dilutions below the resistant category. The activity of cefepime, piperacillin/tazobactam, imipenem, ciprofloxacin and gentamicin make them excellent candidates for the empirical therapy of serious infections due to aerobic Gram-negative bacilli and S aureus.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views46
Downloads172
Citations

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.