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Canadian Journal of Infectious Diseases
Volume 6, Suppl A, Pages 11A-16A

Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy

Peter J Jewesson

Faculty of Pharmaceutical Sciences, University of British Columbia, Department of Pharmacy, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Parenteral to oral stepdown therapy represents an effective cost containment strategy which can minimize intravenous therapy associated morbidity and may facilitate earlier hospital discharge. Several oral anti-infectives are available to the prescriber and there are as many opportunities to stepdown to the same agent as there are to other drugs of the same class or other classes. Recognition of the pharmacokinetic characteristics of these oral agents is essential lo successful therapy. Good bioavailability may not always be assured. A simple regimen will promote compliance.