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Canadian Journal of Infectious Diseases
Volume 11, Suppl D, Pages 4D-10D
Care Pathways

Consensus Guidelines for the Treatment of Infectious Endocarditis with Outpatient Parenteral Antibiotic Therapy

Shurjeel H Choudhri and The Endocarditis Care Plan Working Group

Kingston General Hospital, Kingston, Ontario, Canada

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The development of single, daily dose antibiotic regimens and the availability of computerized ambulatory infusion pumps have made it possible for most patients with infectious endocarditis (IE) to complete their treatment in an outpatient setting. This review summarizes the current literature on the classification, diagnosis, clinical and laboratory manifestations, and inpatient and outpatient management of IE. An algorithmic approach to the diagnosis and management of IE is proposed. Most patients with IE who are clinically stable and do not require a surgical procedure can be managed using outpatient parenteral antibiotic therapy. Results from several small studies suggest that outpatient parenteral antibiotic therapy for IE is safe, efficacious and economical.