Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 2003 / Article

Original Article | Open Access

Volume 14 |Article ID 392617 | https://doi.org/10.1155/2003/392617

Rob D Goddard, Shelly A McNeil, Kathryn L Slayter, R Andrew McIvor, "Antimicrobials in Acute Exacerbations of Chronic Obstructive Pulmonary Disease - An Analysis of the Time to Next Exacerbation Before and After Implementation of Standing Orders", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 14, Article ID 392617, 6 pages, 2003. https://doi.org/10.1155/2003/392617

Antimicrobials in Acute Exacerbations of Chronic Obstructive Pulmonary Disease - An Analysis of the Time to Next Exacerbation Before and After Implementation of Standing Orders

Received27 Nov 2002
Accepted16 May 2003

Abstract

OBJECTIVE: To compare the mean time to next exacerbation in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) before and after the implementation of standing orders.SETTING: Tertiary care hospital, Halifax, Nova Scotia, Canada.POPULATION STUDIED: The records of 150 patients were analyzed, 76 were in the preimplementation group, 74 in the postimplementation group.INTERVENTION: The management and outcomes of patients admitted with an acute exacerbation of COPD before and after the implementation of standing orders were compared.DESIGN: A retrospective chart review.MAIN RESULTS: There was no difference in the mean time to next exacerbation between treatment groups (preimplementation group: 310 days, postimplementation group: 289 days, P=0.53). Antibiotics were used in 90% of the cases (preimplementation group: 87%, postimplementation group: 93%). The postimplementation group had a 20% increase in the use of first-line agents over the preimplementation group. Overall, first-line agents represented only 37% of the antibiotic courses.CONCLUSIONS: The implementation of standing orders encouraged the use of first-line agents but did not influence subsequent symptom resolution, length of hospital stay, or the infection-free interval in patients with acute exacerbations of COPD.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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