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Canadian Journal of Infectious Diseases
Volume 14 (2003), Issue 2, Pages 123-125
http://dx.doi.org/10.1155/2003/675159
Case Report

Cepacia-Like Syndrome Caused by Burkholderia mutivorans

George Zahariadis,1 Michelle H Levy,2 and Jane L Burns3

11Department of Medicine, Division of Infectious Diseases, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
2Department of Family Medicine, Swedish Medical Center, Swedish Physicians Division, 2450 33rd Avenue West, Suite 100, Seattle, Washington 98199, USA
3Department of Pediatrics, Division of Infectious Disease, Rheumatology and Immunology, University of Washington & Children’s Hospital and Regional Medical Center, Box 359300, Seattle, Washington 98195, USA

Received 14 August 2002; Accepted 24 September 2002

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The variable severity of Burkholderia cepacia complex infections in cystic fibrosis (CF) has recently been ascribed to differences in the virulence between genomovars. Specifically, genomovar III isolates have been associated with higher transmission rates and adverse outcomes compared to other B cepacia genomovars, and consequently further segregation between genomovar III and non-genomovar III B cepacia infected patients is advocated in some centres. The important role of non-genomovar III isolates is presented in the context of a clinical case whereby a patient with long-standing pulmonary infection with B multiovorans developed bacteremic infection reminiscent of the fatal 'cepacia syndrome'.